慢性牙周炎中的牙周病致病菌和疱疹病毒。
Periodontopathic bacteria and herpesviruses in chronic periodontitis.
机构信息
Department of Immunology and Medical Biology Research Center, Medical University, Kermanshah, Iran. mchalabi@ kums.ac.ir
出版信息
Mol Oral Microbiol. 2010 Jun;25(3):236-40. doi: 10.1111/j.2041-1014.2010.00571.x.
Periodontal disease involves complex interactions of microorganisms and host defenses. This work investigated the associations between putative bacterial pathogens, herpesviruses and chronic periodontitis. Subgingival samples were collected from 40 periodontally healthy individuals and from 40 patients with chronic periodontitis with probing depths of < or =3 mm or > or =6 mm. Multiplex and nested polymerase chain reactions were used to identify bacterial pathogens and herpesviruses. Porphyromonas gingivalis, Tannerella forsythia, Epstein-Barr virus (EBV) type 1, cytomegalovirus (CMV), Aggregatibacter actinomycetemcomitans and EBV type 2 were detected in, respectively, 95, 75, 72.5, 50, 12.5 and 10% of sites with probing depths > or =6 mm. P. gingivalis, T. forsythia, EBV-1 and CMV were statistically associated with probing depths > or =6 mm. A. actinomycetemcomitans and EBV-2 showed no association with periodontitis sites, and no significant associations were found for any of the test infectious agents and probing depths < or =3 mm. Our results confirm an association between P. gingivalis, T. forsythia, EBV-1 and CMV, and chronic periodontitis. These infectious agents may play an important synergistic role in the pathogenesis of chronic periodontitis.
牙周病涉及微生物和宿主防御的复杂相互作用。本研究调查了假定的细菌病原体、疱疹病毒与慢性牙周炎之间的关联。从牙周健康的 40 名个体和患有探诊深度 <或=3 毫米或 >或=6 毫米的慢性牙周炎的 40 名患者中采集龈下样本。使用多重和嵌套聚合酶链反应来鉴定细菌病原体和疱疹病毒。在分别有探诊深度 >或=6 毫米的 95%、75%、72.5%、50%、12.5%和 10%的位点中检测到牙龈卟啉单胞菌、福赛斯坦纳菌、EB 病毒 1 型、巨细胞病毒、伴放线放线杆菌和 EB 病毒 2 型。牙龈卟啉单胞菌、福赛斯坦纳菌、EBV-1 和 CMV 与探诊深度 >或=6 毫米呈统计学相关。伴放线放线杆菌和 EBV-2 与牙周炎部位无关联，且任何一种测试感染因子与探诊深度 <或=3 毫米均无显著关联。我们的结果证实了牙龈卟啉单胞菌、福赛斯坦纳菌、EBV-1 和 CMV 与慢性牙周炎之间存在关联。这些感染因子可能在慢性牙周炎的发病机制中发挥重要的协同作用。
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