Laboratory of Cellular Ageing, Department of Molecular Biology, Aarhus University, Aarhus, Denmark.
Ann N Y Acad Sci. 2010 Jun;1197:28-32. doi: 10.1111/j.1749-6632.2010.05193.x.
Strategies for testing and developing effective means of intervention, prevention, and modulation of aging incorporate means to minimize the occurrence and accumulation of molecular damage, to reduce molecular heterogeneity, and to evaluate the relevance of the type and extent of damage with respect to its role in aging and age-related diseases. One such approach is that of mild stress-induced hormesis, which stimulates maintenance and repair systems and strengthens the homeodynamic space of cells and organisms. Hormesis through mild heat shock, natural and synthetic hormetins, and other stressors brings about several antiaging effects in human fibroblasts, keratinocytes, and telomerase-immortalized bone marrow stem cells. Depending on the cell type, these antiaging hormetic effects include extension of replicative life span, enhanced proteasomal activities, increased chaperone levels, and improved wound healing, angiogenesis, and differentiation. The main molecular pathways for achieving such hormetic effects are through targeting the processes for the repair and removal of molecular damage, which can slow aging.
测试和开发有效干预、预防和调节衰老的策略包括尽量减少分子损伤的发生和积累、减少分子异质性、评估损伤的类型和程度与衰老和与衰老相关疾病的关系的方法。其中一种方法是温和应激诱导的应激反应，它可以刺激维持和修复系统，增强细胞和生物体的内稳空间。温和热休克、天然和合成的应激素以及其他应激源引起的应激反应在人类成纤维细胞、角质细胞和端粒酶永生化骨髓干细胞中产生了几种抗衰老作用。根据细胞类型的不同，这些抗衰老应激反应包括延长复制寿命、增强蛋白酶体活性、增加伴侣蛋白水平以及改善伤口愈合、血管生成和分化。实现这种应激反应的主要分子途径是通过靶向修复和清除分子损伤的过程，这可以减缓衰老。
