Research Group in Immunophysiology: Exercise, Stress and Health, Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain.
Scand J Med Sci Sports. 2012 Feb;22(1):104-12. doi: 10.1111/j.1600-0838.2010.01132.x. Epub 2010 Jun 1.
Current hypotheses of the etiology of fibromyalgia (FM) include inflammatory disorders. We evaluated the effect of a pool-aquatic exercise program (8 months, two weekly 60-min sessions) on the inflammatory cytokine production by isolated monocytes, and on the serum concentration of C-reactive protein (CRP), in a group of female FM patients. Monocytes from FM patients released more IL-1β, TNFα, IL-6, and IL-10 than those from an age-matched control group of healthy women (HW). This inflammatory disorder in FM women was also manifested by high circulating concentrations of CRP. Increased IL-6 with a concomitant decreased TNFα spontaneous release was found after 4 months (midway through) of the exercise program. At the end of the program (8 months), monocytes from FM patients showed diminished spontaneous production of pro-/anti-inflammatory cytokines, with a similar spontaneous release of IL-1β and IL-6 to that of HW, but a lower production of TNFα and higher of IL-10. Lipopolysaccharide-induced production of IL-1β, TNFα, IL-6, and IL-10 also decreased at the end of the exercise program, although IL-10 remained higher than HW. The anti-inflammatory effect of the exercise program was also corroborated by a decrease in the circulating CRP concentration. Exercise also improved the health-related quality of life of FM patients.
目前，纤维肌痛（FM）病因的假设包括炎症性疾病。我们评估了一个泳池水上运动项目（8 个月，每周两次，每次 60 分钟）对 FM 女性患者分离的单核细胞炎症细胞因子产生和 C 反应蛋白（CRP）血清浓度的影响。与年龄匹配的健康女性（HW）对照组相比，FM 患者的单核细胞释放更多的 IL-1β、TNFα、IL-6 和 IL-10。FM 女性的这种炎症紊乱还表现为 CRP 的循环浓度升高。在运动项目进行到 4 个月（中途）时，发现 IL-6 增加，同时 TNFα 自发释放减少。在项目结束（8 个月）时，FM 患者的单核细胞自发产生促炎/抗炎细胞因子的能力下降，IL-1β 和 IL-6 的自发释放与 HW 相似，但 TNFα 的产生减少，IL-10 的产生增加。运动项目结束时，脂多糖诱导的 IL-1β、TNFα、IL-6 和 IL-10 的产生也减少，尽管 IL-10 仍高于 HW。运动项目的抗炎作用也通过 CRP 浓度的降低得到证实。运动还改善了 FM 患者的健康相关生活质量。
