College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P. R. China.
J Biomater Sci Polym Ed. 2010;21(12):1559-72. doi: 10.1163/092050609X12519805626158. Epub 2010 Jun 9.
A new method for the functional modification of polyethersulfone (PES) is described in this paper in which PES was sulfonated by chlorosulfonic acid firstly and then chlorinated by phosphorus pentachloride. Thereby, chlorosulfonic groups (-SO2Cl) were introduced in PES successfully, and the degree of the chlorosulfonation was about 15%. Since the chlorosulfonic group is reactive enough towards the amino group (-NH2), the conformation of chlorosulfonic-based covalent bonding functional route could further extend the PES application area with versatile functionality. In this article, hydroxyl (-OH), carboxyl (-COOH), amino (-NH2) and methyl (-CH3) groups were grafted onto a PES matrix through the reaction of chlorosulfonic groups and the amino groups. The functional groups have effects on protein adsorption and cell behavior. The membrane modified with an amino group was in favor of cell adhesion and proliferation, and the membrane modified with hydroxyl and methyl did not so well as the membrane modified with an amino group, which will give guidance for biomaterial modification.
本文介绍了一种对聚醚砜（PES）进行功能化修饰的新方法。该方法首先用氯磺酸对 PES 进行磺化，然后用五氯化磷进行氯化，从而成功地在 PES 上引入了氯磺酸基（-SO2Cl），氯磺化程度约为 15%。由于氯磺酸基对氨基（-NH2）具有足够的反应活性，因此基于氯磺酸的共价键功能化路线的构象可以进一步扩展 PES 的应用领域，赋予其多种功能。本文通过氯磺酸基与氨基的反应，将羟基（-OH）、羧基（-COOH）、氨基（-NH2）和甲基（-CH3）基团接枝到 PES 基质上。这些功能基团对蛋白质吸附和细胞行为有影响。经氨基改性的膜有利于细胞黏附与增殖，而经羟基和甲基改性的膜不如经氨基改性的膜，这将为生物材料改性提供指导。
