Department of Immunobiology, King's College London School of Medicine, Guy's Campus, London SE1 9RT, UK.
Curr Opin Immunol. 2010 Aug;22(4):514-20. doi: 10.1016/j.coi.2010.04.009. Epub 2010 May 25.
A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting and activating cells, recent work shows that some subpopulations of B cells can have suppressive functions. The diversity of the B cell population as a whole decreases with age, and is associated with ill health. Whether decreased diversity is a feature of all B cells or a reflection of altered subpopulations is not clear, since different subsets of B cells have different functions and their repertoires are shaped by different selection pressures.
多样化的 B 细胞 repertoire 对于有效的免疫反应至关重要。这不仅提供了多种抗体来识别可能的病原体挑战的多样性，还因为 B 细胞是免疫反应的重要调节剂。除了作为抗原呈递和激活细胞的出色能力外，最近的研究还表明，一些 B 细胞亚群可以具有抑制功能。B 细胞群体的整体多样性随着年龄的增长而降低，并与健康状况不佳有关。多样性的降低是所有 B 细胞的特征还是反映了亚群的改变尚不清楚，因为不同的 B 细胞亚群具有不同的功能，它们的 repertoire 受到不同选择压力的影响。
