新型细胞毒性氮杂萘醌吡咯并稠合衍生物的合成及抗增殖活性：第二部分。
Synthesis and antiproliferative activity of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives: Part II.
机构信息
Department of Drug and Natural Product Synthesis, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria.
出版信息
Bioorg Med Chem Lett. 2011 May 15;21(10):3117-21. doi: 10.1016/j.bmcl.2011.03.013. Epub 2011 Mar 30.
PMID:21458262
Abstract
A series of 6-azanaphthoquinone pyrrolo-annelated derivatives carrying different basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines with Mitoxantrone as reference compound. Cytotoxic effects and DNA intercalation behavior were investigated.
摘要
已经合成了一系列带有不同碱性侧链的 6-氮杂萘醌吡咯并稠合衍生物。以米托蒽醌为参考化合物，评估了所有化合物在至少四种不同细胞系上的抗增殖活性。研究了细胞毒性作用和 DNA 嵌入行为。
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