吡咯并[2,1-c][1,4]苯并二氮杂卓-蒽醌缀合物的合成、DNA结合及细胞毒性研究
Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates.
作者信息
Kamal Ahmed, Ramu R, Tekumalla Venkatesh, Khanna G B Ramesh, Barkume Madan S, Juvekar Aarti S, Zingde Surekha M
机构信息
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
出版信息
Bioorg Med Chem. 2007 Nov 15;15(22):6868-75. doi: 10.1016/j.bmc.2007.08.026. Epub 2007 Aug 23.
PMID:17822905
Abstract
A series of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as anticancer activity. Some of these molecules have shown significant anticancer activity in a number of cancer cell lines.
摘要
一系列吡咯并[2,1-c][1,4]苯并二氮杂卓-蒽醌共轭物已被制备，并对其DNA结合能力和抗癌活性进行了评估。其中一些分子在多种癌细胞系中显示出显著的抗癌活性。
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