Department of Electrical and Computer Engineering, University of British Columbia, 373-2366 Main Mall, Vancouver, BC, V6T 1Z4 Canada.
Med Eng Phys. 2010 Sep;32(7):753-9. doi: 10.1016/j.medengphy.2010.04.017. Epub 2010 May 26.
This paper presents a novel method to estimate the aortic-to-peripheral pulse transit time (PTT) using the blood pressure waveforms measured at two diametric peripheral locations, for instance, one on an upper extremity and the other on a lower extremity. The method is based on a computational relationship between the two peripheral blood pressures, which is derived by first relating each peripheral blood pressure to a common central aortic blood pressure. The parameters of the computational relationship for an individual subject can be identified by fitting them to two peripheral blood pressure waveform measurements, thereby characterizing the cardiovascular dynamics, from which absolute changes in the PTT between the central aorta and each peripheral measurement site can be determined. The strength of the method is that it does not require any a priori knowledge of the peripheral measurement locations nor of the physiologic condition of the cardiovascular system. Experimental results are provided from five healthy swine subjects whose actual PTT experimentally varied from 44.9 ms to 163.0 ms (76.7 ms mean+/-26.4 ms SD). Compared to the reference PTT measurement, the novel method proposed in this paper estimated PTT within 3.7 ms mean+/-4.2 ms SD after initial calibration.
本文提出了一种新的方法，使用在两个不同的外周位置（例如，一个在上肢，另一个在下肢）测量的血压波形来估计主动脉到外周脉搏传输时间（PTT）。该方法基于两个外周血压之间的计算关系，该关系是通过首先将每个外周血压与共同的中心主动脉血压相关联而得出的。个体受试者的计算关系参数可以通过将它们拟合到两个外周血压波形测量值来识别，从而描述心血管动力学，从中可以确定中心主动脉和每个外周测量部位之间的 PTT 的绝对变化。该方法的优点是它不需要任何关于外周测量位置的先验知识，也不需要关于心血管系统的生理状况的先验知识。实验结果来自五个健康的猪科动物，它们的实际 PTT 从 44.9 毫秒到 163.0 毫秒不等（76.7 毫秒平均值+/-26.4 毫秒标准差）。与参考 PTT 测量值相比，本文提出的新方法在初始校准后，估计 PTT 的平均值为 3.7 毫秒+/-4.2 毫秒标准差。
