Permin H, Sestoft L
Acta Med Scand. 1977;202(1-2):113-7. doi: 10.1111/j.0954-6820.1977.tb16795.x.
Biopsies from skin of normal appearance from 18 patients treated with carbamazepine and diphenylhydantoin were investigated by a direct immunofluorescence technique. Seventeen had deposits of plasma proteins at the dermoepidermal junction, 16 had deposits in the vessel walls, and one had autofluorescence of the nuclei in the epidermis and vessel walls. These findings did not correlate with changes in serum IgG, IgA, IgM, IgD, IgE or alpha 2-macroglobulin. Eight patients had elevated alkaline phosphatase, 4 elevated IgG and one elevated IgA. Three had low values of IgA, and all had normal values of IgM, IgD and IgE, and blood cells. In three patients, carbamazepine was withdrawn, whereupon the deposits disappeared in two and decreased in the third, who changed to another drug. The changes were quantitatively and qualitatively similar to those seen in systemic lupud erythematosus induced by these drugs.
采用直接免疫荧光技术对18例接受卡马西平和苯妥英治疗的外观正常皮肤活检标本进行了研究。17例在真皮表皮交界处有血浆蛋白沉积，16例在血管壁有沉积，1例在表皮细胞核和血管壁有自发荧光。这些发现与血清IgG、IgA、IgM、IgD、IgE或α2-巨球蛋白的变化无关。8例碱性磷酸酶升高，4例IgG升高，1例IgA升高。3例IgA值低，所有患者IgM、IgD和IgE以及血细胞值均正常。3例患者停用卡马西平，其中2例沉积物消失，第3例沉积物减少，该患者换用了另一种药物。这些变化在数量和质量上与这些药物诱发的系统性红斑狼疮所见相似。
