Bolton-Maggs P H, Rogan P D, Duguid J K, Mutton K J, Ball L M
Royal Liverpool Children's Hospital, Alder Hey.
Arch Dis Child. 1991 Jun;66(6):732-3. doi: 10.1136/adc.66.6.732.
Eleven haemophiliac boys infected with HIV were screened for irregular red cell antibodies and were compared with nine haemophiliac boys who did not have antibodies to HIV. Seven (64%) of the children who had antibodies to HIV also had cold agglutinins, mostly of anti-I specificity, compared with one (11%) of those who did not have antibodies to HIV. The children with antibodies to HIV and cold agglutinins had a significantly increased mean IgM concentration. The presence of cold agglutinins was not correlated with T4 lymphocyte count, symptoms of HIV infection, serum beta 2 microglobulin concentrations, concentrations of IgG or IgA, or with the evidence of past infection with cytomegalovirus or Epstein-Barr virus.
对11名感染了HIV的血友病男孩进行了不规则红细胞抗体筛查，并与9名未感染HIV抗体的血友病男孩进行了比较。在感染HIV抗体的儿童中，有7名（64%）也有冷凝集素，大多数具有抗-I特异性，而未感染HIV抗体的儿童中这一比例为1名（11%）。感染HIV抗体和冷凝集素的儿童平均IgM浓度显著升高。冷凝集素的存在与T4淋巴细胞计数、HIV感染症状、血清β2微球蛋白浓度、IgG或IgA浓度，或与既往巨细胞病毒或EB病毒感染证据均无相关性。
