Dube V, Iwaki Y, Anderson B, Terasaki P
Vox Sang. 1982;43(3):113-21. doi: 10.1111/j.1423-0410.1982.tb00001.x.
Cytotoxic activity towards B-lymphocytes in sera from individuals with breast carcinoma was related to red blood cell cold agglutinin levels and IgM values. The control group consisted of 32 females with a similar age distribution. Significant increases in red blood cell cold agglutinin levels were found in the group of cancer patients and the group with the histological category of mucin-producing carcinoma with lymphocyte cytotoxins (p less than 0.025, respectively), in comparison to the control group and cancer patients without lymphocyte cytotoxins. Serum IgM concentrations were significantly increased in the group of cancer patients (p less than 0.025) and the group with mucin-producing carcinoma (p less than 0.01) with lymphocyte cytotoxins, in comparison to cancer patients and controls without lymphocyte cytotoxins. The lymphocyte cytotoxins were completely or partially adsorbed by red blood cells in 58% of the positive sera. These results suggest that red blood cell cold agglutinins constitute a portion of cytotoxic anti-B lymphocyte antibodies. At present it is unknown whether the lymphocytotoxic antibodies in breast cancer patients are of importance in immunologic host defenses.
乳腺癌患者血清中对B淋巴细胞的细胞毒性活性与红细胞冷凝集素水平和IgM值相关。对照组由32名年龄分布相似的女性组成。与对照组和无淋巴细胞细胞毒素的癌症患者相比，癌症患者组以及具有淋巴细胞细胞毒素的黏液产生癌组织学类型组的红细胞冷凝集素水平显著升高（分别为p<0.025）。与无淋巴细胞细胞毒素的癌症患者和对照组相比，具有淋巴细胞细胞毒素的癌症患者组（p<0.025）和黏液产生癌组（p<0.01）的血清IgM浓度显著升高。在58%的阳性血清中，淋巴细胞细胞毒素被红细胞完全或部分吸附。这些结果表明，红细胞冷凝集素构成细胞毒性抗B淋巴细胞抗体的一部分。目前尚不清楚乳腺癌患者的淋巴细胞毒性抗体在免疫宿主防御中是否重要。
