Laboratory of Reproductive Medicine, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Hum Immunol. 2010 Sep;71(9):888-91. doi: 10.1016/j.humimm.2010.05.023. Epub 2010 Jun 9.
Accumulated evidence suggested that cytotoxic T-lymphocyte antigen 4 (CTLA4) plays an important role in the negative regulation of T-cell proliferation and activation, and thus participates in antitumor immunity and cancer surveillance. Previously we reported that the CTLA4 49A/G (rs231775) single nucleotide polymorphism (SNP) was a candidate cancer susceptibility marker for breast, lung, esophageal, and gastric cancers. In the present study, we expanded our study to two infection-related cancers, namely, hepatocellular carcinoma (HCC) and cervical cancer. We genotyped rs231775 in two independent case-control studies of 864 HCC patients and 864 control subjects, and 719 cervical cancer patients and 719 control subjects. In the multivariate logistic regression models, CTLA4 +49 A/G variant genotype was associated with increased risk (AA vs GG) by 1.43-fold (95% CI = 0.94-2.17) for HCC, and 1.66-fold (95% CI = 1.13-2.44) for cervical cancer. Taken together, the results suggest that CTLA4 rs231775 may serve as a common cancer susceptibility marker.
累积的证据表明，细胞毒性 T 淋巴细胞抗原 4（CTLA4）在 T 细胞增殖和活化的负调控中发挥重要作用，因此参与抗肿瘤免疫和癌症监测。此前我们报道 CTLA4 49A/G（rs231775）单核苷酸多态性（SNP）是乳腺癌、肺癌、食管癌和胃癌的候选癌症易感性标志物。在本研究中，我们将研究扩展到两种与感染相关的癌症，即肝细胞癌（HCC）和宫颈癌。我们对 864 例 HCC 患者和 864 例对照、719 例宫颈癌患者和 719 例对照进行了 rs231775 的基因分型。在多变量逻辑回归模型中，与 CTLA4 +49A/G 变异基因型相关的 HCC 风险增加（AA 与 GG）1.43 倍（95%CI=0.94-2.17），宫颈癌风险增加 1.66 倍（95%CI=1.13-2.44）。总之，这些结果表明 CTLA4 rs231775 可能是一种常见的癌症易感性标志物。
