Department of Pharmacy Practice, Ferris State University, Kalamazoo, MI, USA.
Pediatr Clin North Am. 2010 Jun;57(3):751-74. doi: 10.1016/j.pcl.2010.02.004.
Both acute and overuse musculoskeletal injuries are common in adolescent athletes. Pharmacologic agents including nonsteroidal anti-inflammatory drugs, acetaminophen, and topical over-the-counter agents have been shown to be effective in controlling pain, but data regarding their efficacy in expediting healing and time to recovery continue to be debated. Studies indicate that adolescents consume analgesic agents on their own and may be unaware of their potential toxicities. Data also indicate that adolescent athletes use medications in hopes of alleviating pain and allowing continuation of sports without adequate time for healing. This article reviews the mechanisms, toxicity, drug interactions, efficacy, and abuse potential of commonly used analgesic and anti-inflammatory drugs.
急性和过度使用的肌肉骨骼损伤在青少年运动员中很常见。包括非甾体抗炎药、对乙酰氨基酚和局部非处方药物在内的药物已被证明可有效控制疼痛，但关于它们在加速愈合和恢复时间方面的疗效的数据仍存在争议。研究表明，青少年自行服用镇痛药，可能并不知道它们潜在的毒性。数据还表明，青少年运动员使用药物是希望缓解疼痛，并在没有足够时间愈合的情况下继续参加运动。本文综述了常用镇痛药和抗炎药的作用机制、毒性、药物相互作用、疗效和滥用潜力。
