Mete A, McDonough S P
California Animal Health and Food Safety Laboratory, University of California, W. Health Science Dr., Davis, CA 95616, USA.
J Comp Pathol. 2011 Jan;144(1):78-81. doi: 10.1016/j.jcpa.2010.04.010. Epub 2010 Jun 9.
A 4-year-old male Shih Tzu died suddenly with the only history being slight lethargy during the previous 2 days. Gross and histopathological examination of the heart revealed severe segmental stenosis of the epicardial coronary artery branches and extensive areas of acute myocardial necrosis interspersed with areas of fibrosis. The segmental coronary artery stenosis was due to smooth muscle and myofibroblast proliferation in the tunica media. The smooth muscle cells and myofibroblasts disrupted the internal elastic lamina and extended into the tunica intima. Thickening of the intima and media was accompanied by fibrosis, consistent with fibromuscular dysplasia. The resulting stenosis led to myocardial infarction and cardiac insufficiency. This report details for the first time the vascular lesions in a case of sudden cardiac death in a dog afflicted with fibromuscular dysplasia of the coronary arteries.
一只4岁雄性西施犬突然死亡，此前仅有的病史是前两天略有嗜睡。对心脏进行大体和组织病理学检查发现，心外膜冠状动脉分支严重节段性狭窄，并有广泛的急性心肌坏死区域，其间夹杂着纤维化区域。节段性冠状动脉狭窄是由于中膜平滑肌和肌成纤维细胞增殖所致。平滑肌细胞和肌成纤维细胞破坏了内弹性膜并延伸至内膜。内膜和中膜增厚并伴有纤维化，符合纤维肌性发育异常。由此导致的狭窄引发了心肌梗死和心功能不全。本报告首次详细描述了一只患有冠状动脉纤维肌性发育异常的犬突然心脏死亡病例中的血管病变情况。
