Yamada A, Nakamoto S, Sakamoto M, Matsumoto T
Department of Laboratory Medicine, Tottori Prefectural Central Hospital.
Kokyu To Junkan. 1993 Jul;41(7):689-92.
An autopsy case involving the dilated phase of hypertrophic cardiomyopathy (HCM) is reported. This case was also complicated with a lesion similar to fibromuscular dysplasia of the coronary artery. A 37 year-old male died of cardiac insufficiency and an autopsy was performed. Macroscopically, both atriums and ventricles were dilated and the walls of both ventricles were markedly thickened. Also, the coronary artery was almost completely obstructed. Histological examination revealed bizarre myocardial hyperplasia with disorganization and marked fibrosis of the myocardium. The coronary artery showed intimal fibrous thickening with increase in elastic fibers and smooth muscle cells. There were similar lesions in other arteries examined; the renal arteries, external iliac arteries, pulmonary arteries and aorta. We think that this lesion of the coronary artery plays an important part in the progression from hypertrophic cardiomyopathy to dilated cardiomyopathy.
报告了一例肥厚型心肌病（HCM）扩张期的尸检病例。该病例还合并有类似冠状动脉纤维肌性发育不良的病变。一名37岁男性死于心脏功能不全并进行了尸检。大体检查显示，心房和心室均扩张，双心室壁明显增厚。此外，冠状动脉几乎完全阻塞。组织学检查显示心肌细胞怪异增生、排列紊乱以及心肌显著纤维化。冠状动脉表现为内膜纤维增厚，弹性纤维和平滑肌细胞增多。在检查的其他动脉，即肾动脉、髂外动脉、肺动脉和主动脉中也发现了类似病变。我们认为冠状动脉的这种病变在肥厚型心肌病向扩张型心肌病的进展过程中起重要作用。
