Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Curr Opin Cell Biol. 2010 Aug;22(4):513-8. doi: 10.1016/j.ceb.2010.05.009. Epub 2010 Jun 10.
Receptor-mediated endocytosis is important for the selective internalization of membrane proteins. In mammals, clathrin, adaptors, and dynamin play prominent roles in regulating cargo selection and vesicle formation. Endocytosis in yeast is generally conserved, but exhibits significant and perplexing differences in the relative importance of clathrin adaptors, dynamin-like proteins, and actin. Recent studies are now reconciling divergent views of endocytic processes in yeast and mammals. The discovery of cargo-specific functions for yeast homologs of mammalian clathrin adaptors has rapidly expanded the number of endocytic adaptors in yeast. Moreover, unifying models have been advanced to explain how dynamin, actin, and membrane-deforming proteins drive membrane scission. While differences remain, discoveries from each system will continue to inform the other.
受体介导的内吞作用对于膜蛋白的选择性内化非常重要。在哺乳动物中，网格蛋白、衔接蛋白和动力蛋白在调节货物选择和囊泡形成方面发挥着重要作用。酵母中的内吞作用通常是保守的，但在网格蛋白衔接蛋白、类似动力蛋白的蛋白和肌动蛋白的相对重要性方面存在显著且令人费解的差异。最近的研究正在调和酵母和哺乳动物中内吞作用过程的不同观点。发现酵母中哺乳动物网格蛋白衔接蛋白的同源物具有货物特异性功能，这迅速增加了酵母中内吞作用衔接蛋白的数量。此外，还提出了统一的模型来解释动力蛋白、肌动蛋白和膜变形蛋白如何驱动膜的分裂。尽管存在差异，但每个系统的发现仍将相互借鉴。
