Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, TX 78712, USA.
Curr Opin Biotechnol. 2010 Aug;21(4):392-400. doi: 10.1016/j.copbio.2010.05.003. Epub 2010 Jun 9.
Nucleic acid-based nanotechnology has always been perceived as novel, but has begun to move from theoretical demonstrations to practical applications. In particular, the large address spaces available to nucleic acids can be exploited to encode algorithms and/or act as circuits and thereby process molecular information. In this review we not only revisit several milestones in the field of nucleic acid-based computation, but also highlight how the prospects for nucleic acid computation go beyond just a large address space. Functional nucleic acid elements (aptamers, ribozymes, and deoxyribozymes) can serve as inputs and outputs to the environment, and can act as logical elements. Into the future, the chemical dynamics of nucleic acids may prove as useful as hybridization for computation.
基于核酸的纳米技术一直被认为是新颖的，但已开始从理论论证转向实际应用。特别是，核酸提供的大地址空间可用于编码算法和/或充当电路，从而处理分子信息。在这篇综述中，我们不仅回顾了基于核酸的计算领域的几个里程碑，还强调了核酸计算的前景不仅仅局限于大地址空间。功能性核酸元件（适体、核酶和脱氧核酶）可用作与环境相互作用的输入和输出，并可充当逻辑元件。未来，核酸的化学动力学可能像杂交一样对计算有用。
