Purnick Priscilla E M, Weiss Ron
Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA.
Nat Rev Mol Cell Biol. 2009 Jun;10(6):410-22. doi: 10.1038/nrm2698.
Synthetic biology is a research field that combines the investigative nature of biology with the constructive nature of engineering. Efforts in synthetic biology have largely focused on the creation and perfection of genetic devices and small modules that are constructed from these devices. But to view cells as true 'programmable' entities, it is now essential to develop effective strategies for assembling devices and modules into intricate, customizable larger scale systems. The ability to create such systems will result in innovative approaches to a wide range of applications, such as bioremediation, sustainable energy production and biomedical therapies.
合成生物学是一个将生物学的探索性质与工程学的构建性质相结合的研究领域。合成生物学的工作主要集中在基因装置以及由这些装置构建的小模块的创建和完善上。但是，要将细胞视为真正的“可编程”实体，现在必须制定有效的策略，将装置和模块组装成复杂的、可定制的更大规模系统。创建此类系统的能力将带来广泛应用的创新方法，例如生物修复、可持续能源生产和生物医学疗法。
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