Serov R A, Sokolova N N
Arkh Anat Gistol Embriol. 1991 Jan;100(1):9-14.
A quantitative histo-fluorescent investigation of the adrenal medulla and cardiac sympathetic nerves in young rats of various age has demonstrated a high degree in development of the adrenal medulla and a low density in arrangement of fluorescent nervous terminals in the ventricular myocardium in 3-week-old rats. During this period the animals show a low sensitivity to the catecholamine stress. At the age of 1.5 months the development of the sympatho-adrenomedullary system reaches the level specific for a mature animal; sensitivity to the norepinephrine stress increases noticeably, manifesting as a sharp activation of catecholamines secretion by the adrenal medulla and a high lethality.
对不同年龄幼鼠肾上腺髓质和心脏交感神经进行的定量组织荧光研究表明，3周龄大鼠的肾上腺髓质发育程度较高，而心室心肌中荧光神经末梢的排列密度较低。在此期间，动物对儿茶酚胺应激的敏感性较低。在1.5月龄时，交感-肾上腺髓质系统的发育达到成熟动物的特定水平；对去甲肾上腺素应激的敏感性显著增加，表现为肾上腺髓质儿茶酚胺分泌的急剧激活和高致死率。
