Serov R A, Sokolova N N
Arkh Anat Gistol Embriol. 1987 Feb;92(2):36-9.
The sympathetic innervation of the cardiac ventricles and dynamics of catecholamine contents in the adrenal medulla have been investigated in inbred white rats (1-3-week-old, immature, mature and old animals). During 1-3 weeks of age, development of adrenergic innervation of the heart is observed, in 1.5-month-old rats in approaches that in mature animals. In the old rats the arrangement density and fluorescent intensity of the adrenergic terminals of the cardiac ventricles in comparison to those in the mature animals decreases considerably. Catecholamine contents in the adrenal medulla in 3-week-old rats practically reaches those specific for mature animals. In the old animals the amount of catecholamines in the adrenal medulla decreases by 20%, comparing to those in the mature animals. Thus, maturation of the mediator link of the sympatho-adrenomedullary system is performed in it later than the hormonal one, while processes of old age involution are more intensive.
对近交系白色大鼠（1 - 3周龄、未成熟、成熟和老年动物）的心室交感神经支配以及肾上腺髓质中儿茶酚胺含量的动态变化进行了研究。在1 - 3周龄期间，观察到心脏肾上腺素能神经支配的发育，1.5月龄大鼠的情况与成熟动物相近。与成熟动物相比，老年大鼠心室肾上腺素能终末的排列密度和荧光强度显著降低。3周龄大鼠肾上腺髓质中的儿茶酚胺含量实际上已达到成熟动物的特定水平。与成熟动物相比，老年动物肾上腺髓质中的儿茶酚胺量减少了20%。因此，交感 - 肾上腺髓质系统介质环节的成熟在该系统中比激素环节的成熟要晚，而老年退化过程更为强烈。
