Department of Ophthalmology, Kings College London, Rayne Institute, St. Thomas' Hospital, London, United Kingdom.
Invest Ophthalmol Vis Sci. 2011 Apr 25;52(5):2741-8. doi: 10.1167/iovs.09-4493.
To determine whether the volume of retinal tissue passing between the inner and outer retina in macular edema could be used as an indicator of visual acuity.
Diabetic and uveitic patients with cystoid macular edema (81 subjects, 129 eyes) were recruited. Best corrected logMAR visual acuity and spectral optical coherence tomography (OCT/SLO; OTI, Toronto, ONT, Canada) were performed in all patients. Coronal OCT scans obtained from a cross section of the retina between the plexiform layers were analyzed with a grid of five concentric radii (500, 1000, 1500, 2000, and 2500 μm centered on the fovea). The images were analyzed to determine the amount of retinal tissue present within each ring. A linear regression model was developed to determine the relationship between tissue integrity and logMAR visual acuity.
A linear relationship between tissue integrity and VA was demonstrated. The volume of retinal tissue between the plexiform layers in rings 1 and 2 (up to 1000 μm from the foveal center) predicted 80% of visual acuity. By contrast, central macular thickness within the central 1000 μm predicted only 14% of visual acuity.
This study showed that the cross-sectional area of retinal tissue between the plexiform layers in cystoid macular edema, as imaged by OCT, is the best indicator of visual function at baseline. Further prospective treatment trials are needed to investigate this parameter as a predictor of visual outcome after intervention.
确定在黄斑水肿中穿过内、外视网膜之间的视网膜组织量是否可作为视力的指标。
招募了患有囊样黄斑水肿的糖尿病和葡萄膜炎患者（81 例，129 只眼）。所有患者均进行最佳矫正对数视力和光谱光学相干断层扫描（OCT/SLO；OTI，多伦多，ONT，加拿大）。在视盘层之间的视网膜的横截面处获得的冠状 OCT 扫描，用 5 个同心半径（以黄斑中心为中心的 500、1000、1500、2000 和 2500μm）的网格进行分析。对图像进行分析，以确定每个环内存在的视网膜组织量。建立了线性回归模型，以确定组织完整性与 logMAR 视力之间的关系。
证明了组织完整性与 VA 之间存在线性关系。在环 1 和 2 （距黄斑中心 1000μm 以内）的神经层之间的视网膜组织量预测了 80％的视力。相比之下，中心 1000μm 以内的中央黄斑厚度仅预测了 14％的视力。
本研究表明，OCT 成像的囊样黄斑水肿中神经层之间的视网膜组织横截面积是基线时视力功能的最佳指标。需要进一步进行前瞻性治疗试验，以研究该参数作为干预后视觉结果的预测指标。
