Novy M J
Ciba Found Symp. 1977(47):259-95. doi: 10.1002/9780470720295.ch11.
Indomethacin administration in late pregnancy prolonged gestation in caged rhesus monkeys and inhibited premature labour and postponed delivery in chronically catheterized monkey fetuses. Chronic indomethacin treatment was associated with a reduction in the urinary excretion of a prostaglandin metabolite, a potent inhibitory effect on myometrial cyclic AMP phosphodiesterase, and severe oligohydramnios in pre-term and post-term fetuses. Experimental anencephaly (functional hypophysectomy) of the rhesus fetus results in lowered concentrations of maternal oestradiol and loss of the precise control of gestational length, with 40% of fetuses delivering beyond term. Corticotropin (ACTH) infused into the fetus results in raised concentrations of fetal and maternal cortisol, progesterone and oestrogens. Progesterone concentrations in peripheral blood apparently have little bearing on uterine quiescence in the rhesus monkey, since the concentrations of progesterone in maternal and fetal blood vary directly with uterine activity. The results of chronic infusion of corticotropin in the fetal monkey support the theory that in the monkey parturition is mediated by increased oestrogen production by the fetoplacental unit and by a rise in the concentrations of oestrone and prostaglandin in the amniotic fluid.
在妊娠晚期给笼养恒河猴注射吲哚美辛可延长妊娠期，并抑制早产，使长期插管的猴胎儿的分娩推迟。长期使用吲哚美辛治疗与前列腺素代谢产物尿排泄减少、对子宫肌层环磷酸腺苷磷酸二酯酶有强烈抑制作用以及早产和足月胎儿出现严重羊水过少有关。恒河猴胎儿实验性无脑畸形（功能性垂体切除）会导致母体雌二醇浓度降低以及妊娠期长度精确控制的丧失，40%的胎儿会过期分娩。向胎儿输注促肾上腺皮质激素（ACTH）会导致胎儿和母体皮质醇、孕酮和雌激素浓度升高。恒河猴外周血中的孕酮浓度显然与子宫静止关系不大，因为母体和胎儿血液中的孕酮浓度与子宫活动直接相关。在胎儿恒河猴中慢性输注促肾上腺皮质激素的结果支持了这样一种理论，即在恒河猴中分娩是由胎儿胎盘单位雌激素生成增加以及羊水中雌酮和前列腺素浓度升高介导的。
