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Correct intron splicing generates a new type of a putative zinc-binding domain in a transcriptional activator of Aspergillus nidulans.

作者信息

Kulmburg P, Prangé T, Mathieu M, Sequeval D, Scazzocchio C, Felenbok B

机构信息

Institut de Génétique et Microbiologie, Centre Universitaire Paris-Sud, Orsay, France.

出版信息

FEBS Lett. 1991 Mar 11;280(1):11-6. doi: 10.1016/0014-5793(91)80193-7.

DOI:10.1016/0014-5793(91)80193-7
PMID:2053973
Abstract

alcR is the pathway-specific transcriptional activator of the ethanol regulon in the filamentous fungus, Aspergillus nidulans. The deduced amino acid sequence of a cDNA clone, including the 5' part of the alcR-mRNA, shows that a putative Zn-binding domain of the all-cysteine class, exemplified by GAL4 is present. This structure presents some striking features. At variance with other structures of this class, the binding domain is strongly asymmetrical. Model building indicates that the zinc-binding motif of alcR could adopt an helix-turn-helix structure. We propose that the DNA-binding motif of alcR could participate in two types of DNA-binding structures: the zinc-cluster and the helix-turn-helix.

摘要

相似文献

1
Correct intron splicing generates a new type of a putative zinc-binding domain in a transcriptional activator of Aspergillus nidulans.
FEBS Lett. 1991 Mar 11;280(1):11-6. doi: 10.1016/0014-5793(91)80193-7.
2
Identification of the promoter region involved in the autoregulation of the transcriptional activator ALCR in Aspergillus nidulans.构巢曲霉中转录激活因子ALCR自调控相关启动子区域的鉴定
Mol Cell Biol. 1992 May;12(5):1932-9. doi: 10.1128/mcb.12.5.1932-1939.1992.
3
nirA, the pathway-specific regulatory gene of nitrate assimilation in Aspergillus nidulans, encodes a putative GAL4-type zinc finger protein and contains four introns in highly conserved regions.nirA是构巢曲霉中硝酸盐同化作用的途径特异性调控基因，编码一种假定的GAL4型锌指蛋白，且在高度保守区域含有四个内含子。
Mol Cell Biol. 1991 Nov;11(11):5746-55. doi: 10.1128/mcb.11.11.5746-5755.1991.
4
Relationship between zinc content and DNA-binding activity of the DNA-binding motif of the transcription factor ALCR in Aspergillus nidulans.构巢曲霉中转录因子ALCR的DNA结合基序的锌含量与DNA结合活性之间的关系
Mol Gen Genet. 1994 Jan;242(1):33-9. doi: 10.1007/BF00277345.
5
Specific binding sites in the alcR and alcA promoters of the ethanol regulon for the CREA repressor mediating carbon catabolite repression in Aspergillus nidulans.构巢曲霉中乙醇调节子的alcR和alcA启动子上的特异性结合位点，用于CREA阻遏物介导碳分解代谢物阻遏。
Mol Microbiol. 1993 Mar;7(6):847-57. doi: 10.1111/j.1365-2958.1993.tb01175.x.
6
A single amino acid, outside the AlcR zinc binuclear cluster, is involved in DNA binding and in transcriptional regulation of the alc genes in Aspergillus nidulans.在构巢曲霉中，位于AlcR锌双核簇之外的单个氨基酸参与DNA结合以及alc基因的转录调控。
Mol Microbiol. 1999 Feb;31(4):1115-24. doi: 10.1046/j.1365-2958.1999.01250.x.
7
The solution structure of an AlcR-DNA complex sheds light onto the unique tight and monomeric DNA binding of a Zn(2)Cys(6) protein.一种AlcR-DNA复合物的溶液结构揭示了一种Zn(2)Cys(6)蛋白独特的紧密且单体形式的DNA结合方式。
Structure. 2001 Sep;9(9):827-36. doi: 10.1016/s0969-2126(01)00640-2.
8
In vivo studies of upstream regulatory cis-acting elements of the alcR gene encoding the transactivator of the ethanol regulon in Aspergillus nidulans.构巢曲霉中编码乙醇调节子反式激活因子的alcR基因上游调控顺式作用元件的体内研究。
Mol Microbiol. 2000 Apr;36(1):123-31. doi: 10.1046/j.1365-2958.2000.01833.x.
9
Unique DNA binding specificity of the binuclear zinc AlcR activator of the ethanol utilization pathway in Aspergillus nidulans.构巢曲霉乙醇利用途径中双核锌激活剂AlcR的独特DNA结合特异性
J Biol Chem. 1999 Apr 2;274(14):9795-802. doi: 10.1074/jbc.274.14.9795.
10
Specific binding sites for the activator protein, ALCR, in the alcA promoter of the ethanol regulon of Aspergillus nidulans.构巢曲霉乙醇调节子的alcA启动子中激活蛋白ALCR的特异性结合位点。
J Biol Chem. 1992 Oct 15;267(29):21146-53.

引用本文的文献

1
Differential chemical labeling of the AlcR DNA-binding domain from Aspergillas nidulans versus its complex with a 16-mer DNA target: identification of an essential tryptophan involved in the recognition and the interaction with the nucleic acid.构巢曲霉AlcR DNA结合结构域与其16聚体DNA靶标复合物的差异化学标记：鉴定参与核酸识别和相互作用的必需色氨酸。
Protein Sci. 2001 Jan;10(1):99-107. doi: 10.1110/ps.28201.
2
The regulator of nitrate assimilation in ascomycetes is a dimer which binds a nonrepeated, asymmetrical sequence.子囊菌中硝酸盐同化作用的调节因子是一种二聚体，它结合一个非重复的不对称序列。
Mol Cell Biol. 1998 Mar;18(3):1339-48. doi: 10.1128/MCB.18.3.1339.
3
A study of protein-water exchange through the off-resonance ROESY experiment: application to the DNA-binding domain of AlcR.
J Biomol NMR. 1996 Dec;8(4):487-91. doi: 10.1007/BF00228149.
4
Ethanol utilization regulatory protein: profile alignments give no evidence of origin through aldehyde and alcohol dehydrogenase gene fusion.乙醇利用调节蛋白：序列比对未发现其起源于醛脱氢酶和醇脱氢酶基因融合的证据。
Protein Sci. 1995 Dec;4(12):2621-4. doi: 10.1002/pro.5560041221.
5
Relationship between zinc content and DNA-binding activity of the DNA-binding motif of the transcription factor ALCR in Aspergillus nidulans.构巢曲霉中转录因子ALCR的DNA结合基序的锌含量与DNA结合活性之间的关系
Mol Gen Genet. 1994 Jan;242(1):33-9. doi: 10.1007/BF00277345.
6
Functional analysis of the zinc cluster domain of the CYP1 (HAP1) complex regulator in heme-sufficient and heme-deficient yeast cells.在血红素充足和血红素缺乏的酵母细胞中对CYP1（HAP1）复合调节因子的锌簇结构域进行功能分析。
Mol Gen Genet. 1994 Mar;242(6):699-707. doi: 10.1007/BF00283425.
7
The Aspergillus nidulans CREA protein mediates glucose repression of the ethanol regulon at various levels through competition with the ALCR-specific transactivator.构巢曲霉CREA蛋白通过与ALCR特异性反式激活因子竞争，在多个水平介导乙醇调节子的葡萄糖阻遏作用。
EMBO J. 1994 Sep 1;13(17):4022-7. doi: 10.1002/j.1460-2075.1994.tb06718.x.
8
Sequence of the HAP3 transcription factor of Kluyveromyces lactis predicts the presence of a novel 4-cysteine zinc-finger motif.乳酸克鲁维酵母HAP3转录因子的序列预测存在一种新型的4-半胱氨酸锌指基序。
Mol Gen Genet. 1994 Oct 17;245(1):96-106. doi: 10.1007/BF00279755.
9
Overexpression of two penicillin structural genes in Aspergillus nidulans.构巢曲霉中两个青霉素结构基因的过表达。
Mol Gen Genet. 1995 Jan 6;246(1):110-8. doi: 10.1007/BF00290139.
10
The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae.构巢曲霉嘌呤利用途径的特异性调节因子UaY的序列和结合特异性表明，它与酿酒酵母的PPR1蛋白存在进化关系。
EMBO J. 1995 Apr 3;14(7):1453-67. doi: 10.1002/j.1460-2075.1995.tb07132.x.