Beyond neuroprotection to brain repair: exploring the next frontier in clinical neuroscience to expand the therapeutic window for stroke.
作者信息
Ratan Rajiv R
机构信息
Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605 USA.
出版信息
Transl Stroke Res. 2010 Jun;1(2):71-3. doi: 10.1007/s12975-010-0024-6. Epub 2010 May 18.
Abstract
摘要
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Years of disability-adjusted life gained as a result of thrombolytic therapy for acute ischemic stroke.溶栓治疗急性缺血性脑卒中获得的多年伤残调整生命年。
Stroke. 2010 Mar;41(3):471-7. doi: 10.1161/STROKEAHA.109.571083. Epub 2010 Feb 4.
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Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats.NEP 1-40 治疗与运动训练联合促进大鼠局灶性皮质梗死后的行为恢复。
Stroke. 2010 Mar;41(3):544-9. doi: 10.1161/STROKEAHA.109.572073. Epub 2010 Jan 14.
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A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.大规模的化学筛选发现，调节精氨酸酶 1 启动子的物质中，大豆异黄酮染料木黄酮是一种已被临床认可的小分子，可以通过非 cAMP 依赖途径促进神经元的保护或再生。
J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.
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Plasticity during stroke recovery: from synapse to behaviour.中风恢复过程中的可塑性：从突触到行为。
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