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Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury.埃洛烷类化合物是一类新型的内稳态脂质介质，能够保护神经细胞在损伤时的完整性。
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Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke.新型阿司匹林触发的神经保护素 D1 可减轻实验性中风后的脑缺血损伤。
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Prolonged exposure to isoflurane ameliorates infarction severity in the rat pup model of neonatal hypoxia-ischemia.长时间接触异氟醚可改善新生大鼠缺氧缺血模型的梗死严重程度。
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本文引用的文献

1
Angiogenesis, neurogenesis and brain recovery of function following injury.损伤后血管生成、神经发生与脑功能恢复
Curr Opin Investig Drugs. 2010 Mar;11(3):298-308.
2
Years of disability-adjusted life gained as a result of thrombolytic therapy for acute ischemic stroke.溶栓治疗急性缺血性脑卒中获得的多年伤残调整生命年。
Stroke. 2010 Mar;41(3):471-7. doi: 10.1161/STROKEAHA.109.571083. Epub 2010 Feb 4.
3
Combination of NEP 1-40 treatment and motor training enhances behavioral recovery after a focal cortical infarct in rats.NEP 1-40 治疗与运动训练联合促进大鼠局灶性皮质梗死后的行为恢复。
Stroke. 2010 Mar;41(3):544-9. doi: 10.1161/STROKEAHA.109.572073. Epub 2010 Jan 14.
4
A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.大规模的化学筛选发现，调节精氨酸酶 1 启动子的物质中，大豆异黄酮染料木黄酮是一种已被临床认可的小分子，可以通过非 cAMP 依赖途径促进神经元的保护或再生。
J Neurosci. 2010 Jan 13;30(2):739-48. doi: 10.1523/JNEUROSCI.5266-09.2010.
5
Plasticity during stroke recovery: from synapse to behaviour.中风恢复过程中的可塑性：从突触到行为。
Nat Rev Neurosci. 2009 Dec;10(12):861-72. doi: 10.1038/nrn2735. Epub 2009 Nov 4.
6
HDAC6 is a target for protection and regeneration following injury in the nervous system.组蛋白去乙酰化酶6（HDAC6）是神经系统损伤后保护和再生的一个靶点。
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19599-604. doi: 10.1073/pnas.0907935106. Epub 2009 Nov 2.
7
Translating the frontiers of brain repair to treatments: starting not to break the rules.将脑修复的前沿转化为治疗方法：从避免破坏规则开始。
Neurobiol Dis. 2010 Feb;37(2):237-42. doi: 10.1016/j.nbd.2009.09.005. Epub 2009 Sep 18.
8
Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke.发育和病理过程中的脑 angiogenesis：中风后的神经血管损伤和血管生成恢复。 （注：angiogenesis 可能拼写有误，正确的是 angiogenesis，意为血管生成）
FEBS J. 2009 Sep;276(17):4644-52. doi: 10.1111/j.1742-4658.2009.07176.x. Epub 2009 Jul 31.
9
A decision algorithm for translating preclinical trial results to enhance recovery after stroke.一种用于转化临床前试验结果以促进中风后恢复的决策算法。
J Biopharm Stat. 2009;19(1):204-16. doi: 10.1080/10543400802536271.
10
Experience-dependent plasticity from eye opening enables lasting, visual cortex-dependent enhancement of motion vision.睁眼后依赖经验的可塑性能够实现持久的、依赖视觉皮层的运动视觉增强。
J Neurosci. 2008 Sep 24;28(39):9817-27. doi: 10.1523/JNEUROSCI.1940-08.2008.

Beyond neuroprotection to brain repair: exploring the next frontier in clinical neuroscience to expand the therapeutic window for stroke.

作者信息

Ratan Rajiv R

机构信息

Burke-Cornell Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605 USA.

出版信息

Transl Stroke Res. 2010 Jun;1(2):71-3. doi: 10.1007/s12975-010-0024-6. Epub 2010 May 18.

DOI:10.1007/s12975-010-0024-6
PMID:20539747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2881323/
Abstract
摘要