Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, USA.
Thromb Haemost. 2010 Sep;104(3):432-9. doi: 10.1160/TH09-11-0771. Epub 2010 Jun 10.
Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.
血栓形成或血栓形成的并发症,目前在发达国家心血管疾病发病率和死亡率的前三位。预防和治疗血栓形成的安全有效的药物数量有限。需要血栓形成的动物模型来更好地了解形成血栓的复杂成分和相互作用。组织因子(TF)是血液凝固起始所必需的,可能在动脉和静脉血栓形成中起关键作用。了解 TF 在血栓形成中的作用可能允许开发新的抗血栓药物。本文综述主要关注 TF 在血栓形成的体内模型中的作用。