Salafet O V, Ruzina N D, Ponomarenko N A, Friboulet A, Kimova M V, Shmidt T E, Gabibov A G, Morse H K, Pal'tsev M A, Suchkov S V
Vestn Ross Akad Med Nauk. 2010(4):8-15.
Disseminated sclerosis is currently regarded as a CNS autoimmune disease. One of the mechanisms behind this pathology is antibody (AB) formation. In this context, recent data on AB with proteolytic activity are of importance because they participate in selective proteolysis of myelin proteins in patients with disseminated sclerosis. This paper focuses on AB-proteases associated with disseminated sclerosis and site-specificity of antibody-mediated proteolysis of myelin basic protein. Protocol of serodiagnostic algorithm to be used in clinical practice is described.
播散性硬化症目前被视为一种中枢神经系统自身免疫性疾病。这种病理背后的机制之一是抗体（AB）的形成。在这种情况下，关于具有蛋白水解活性的抗体的最新数据很重要，因为它们参与了播散性硬化症患者髓鞘蛋白的选择性蛋白水解。本文重点关注与播散性硬化症相关的AB蛋白酶以及抗体介导的髓鞘碱性蛋白蛋白水解的位点特异性。描述了将在临床实践中使用的血清诊断算法方案。
