Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China.
J Am Chem Soc. 2010 Jul 7;132(26):8900-2. doi: 10.1021/ja103426d.
A new, efficient Cu-catalyzed intramolecular C-H oxidation/acylation method has been developed for the synthesis of substituted indoline-2,3-diones (isatins). In the presence of CuCl(2) and O(2), a variety of formyl-N-arylformamides underwent the tandem reaction to afford the corresponding indoline-2,3-diones in moderate to good yields. It is noteworthy that the reaction serves as the first example of transition-metal-catalyzed transformation for the preparation of indoline-2,3-diones.
一种新的、高效的铜催化的分子内 C-H 氧化/酰化方法已经被开发出来，用于合成取代的吲哚啉-2,3-二酮（色满酮）。在 CuCl(2) 和 O(2)的存在下，各种甲酰-N-芳甲酰胺经历串联反应，以中等至良好的收率得到相应的吲哚啉-2,3-二酮。值得注意的是，该反应是首例过渡金属催化转化用于制备吲哚啉-2,3-二酮的例子。
