铜催化游离（N-H）吲哚与α-氧代羧酸的 C3-酰化脱羧反应。

Copper-catalyzed decarboxylative C3-acylation of free (N-H) indoles with α-oxocarboxylic acids.

机构信息

Key Laboratory for Functional Material, Educational Department of Liaoning Province, University of Science and Technology Liaoning, Anshan, 114051, P. R. China.

出版信息

Org Biomol Chem. 2014 Mar 21;12(11):1721-4. doi: 10.1039/c3ob42171f.

DOI:10.1039/c3ob42171f

PMID:24514028

Abstract

An efficient Cu-catalyzed decarboxylative C3-acylation of free (N-H) indoles using α-oxocarboxylic acids as acylating agents has been developed. This method was compatible with a variety of functional groups and provided an attractive alternative access to 3-acylindoles in moderate to high yields.

摘要

一种高效的 Cu 催化的脱羧 C3-酰化游离（N-H）吲哚的方法已经被开发出来，该方法使用α-氧代羧酸作为酰化试剂。该方法与多种官能团兼容，并提供了一种有吸引力的替代方法，以中等到高产率得到 3-酰基吲哚。