铜催化的 α-氨基羰基化合物的 C-H 氧化/交叉偶联。
Copper-catalyzed C-H oxidation/cross-coupling of α-amino carbonyl compounds.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
出版信息
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3453-7. doi: 10.1002/anie.201109027. Epub 2012 Feb 29.
PMID:22378689
Abstract
Keeping options open: the new and mild title reaction involving indoles selectively furnishes 1 and 2 with the aid of tert-butyl hydroperoxide (TBHP). The method represents the first example of a copper-catalyzed α arylation of α-amino carbonyl substrates leading to α-aryl α-imino and α-aryl α-oxo carbonyl compounds using a C-H oxidation strategy.
摘要
保持选择的开放性
新的温和的标题反应涉及吲哚，通过叔丁基过氧化氢（TBHP）选择性地提供 1 和 2。该方法代表了铜催化的α-氨基羰基底物的α-芳基化的第一个例子，该方法使用 C-H 氧化策略得到α-芳基α-亚氨基和α-芳基α-氧羰基化合物。
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