Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany.
J Infect Dis. 2010 Jul 15;202(2):313-7. doi: 10.1086/653586.
Among 62 children with mild malaria, cerebral malaria, or severe malarial anemia, we analyzed the transcription of different var gene types. There was no difference in parasitemia level or body temperature between groups. However, a significantly different expression pattern was observed in children with cerebral malaria, compared with that in patients in the other 2 groups: children with cerebral malaria had lower expression of the upsA subtype but higher expression of the upsB and upsC subtypes. Furthermore, expression of human genes responsive to tumor necrosis factor and hypoxia correlated with distinct ups types.
在 62 名患有轻度疟疾、脑型疟疾或严重疟疾性贫血的儿童中，我们分析了不同 var 基因类型的转录。各组之间的寄生虫血症水平或体温没有差异。然而，与其他 2 组患者相比，脑型疟疾患儿的表达模式存在显著差异：脑型疟疾患儿 upsA 亚型的表达较低，但 upsB 和 upsC 亚型的表达较高。此外，对肿瘤坏死因子和缺氧有反应的人类基因的表达与不同的 ups 类型相关。
