Department of Cardiology, Etlik Ihtisas Research and Education Hospital, Ministry of Health, Ankara, Turkey.
Ren Fail. 2010 Jul;32(6):659-65. doi: 10.3109/0886022X.2010.485288.
Microalbuminuria is associated with atherosclerosis and it is a strong and independent predictor of increased risk for cardiovascular morbidity and mortality. However, the underlying mechanisms of the association of albuminuria and cardiovascular disease are not well understood. We examined the association of endothelial dysfunction with microalbuminuria in non-diabetic and non-hypertensive patients with acute coronary syndromes (ACS).
We compared endothelial function by flow-mediated dilatation (FMD) and glyceryl trinitrate-mediated dilatation (GTN) and angiographic properties among 27 microalbuminuric and 106 normoalbuminuric patients. Severity of coronary arteriosclerosis was evaluated using the Gensini score and number of diseased vessels.
We evaluated 133 patients (106 males; mean age 59 +/- 11 years). Microalbuminuria was present in 27 (20.3%) subjects. Patients with microalbuminuria and normoalbuminuria had similar baseline characteristics. FMD and GTN responses were not different in microalbuminuric patients compared with normoalbuminuric patients (FMD 8.2 +/- 5.3 vs. 7.9 +/- 6.5%, p = 0.54 and GTN 9.3 +/- 5.4 vs. 10.2 +/- 6.9%, p = 0.82). Microalbuminuria was not associated with endothelial dysfunction (p = 0.49). Morphological properties of coronary lesion were not different.
The presence of microalbuminuria is not associated with endothelial dysfunction and severity of angiographic coronary atherosclerosis in non-diabetic and non-hypertensive patients with ACS.
微量白蛋白尿与动脉粥样硬化有关，是心血管发病率和死亡率增加的一个强有力的独立预测因素。然而，白蛋白尿与心血管疾病之间的关联的潜在机制尚不清楚。我们检查了非糖尿病和非高血压急性冠状动脉综合征（ACS）患者微量白蛋白尿与内皮功能障碍的关系。
我们比较了 27 例微量白蛋白尿患者和 106 例正常白蛋白尿患者的内皮功能（通过血流介导的扩张（FMD）和硝酸甘油介导的扩张（GTN））和血管造影特征。采用 Gensini 评分和病变血管数评价冠状动脉粥样硬化严重程度。
我们评估了 133 例患者（106 例男性；平均年龄 59 +/- 11 岁）。27 例（20.3%）患者存在微量白蛋白尿。微量白蛋白尿和正常白蛋白尿患者的基线特征相似。与正常白蛋白尿患者相比，微量白蛋白尿患者的 FMD 和 GTN 反应无差异（FMD 8.2 +/- 5.3 对 7.9 +/- 6.5%，p = 0.54 和 GTN 9.3 +/- 5.4 对 10.2 +/- 6.9%，p = 0.82）。微量白蛋白尿与内皮功能障碍无关（p = 0.49）。冠状动脉病变的形态学特征无差异。
在非糖尿病和非高血压 ACS 患者中，微量白蛋白尿的存在与内皮功能障碍和血管造影冠状动脉粥样硬化的严重程度无关。
