Department of Pediatrics, Peking University First Hospital, Beijing, 100034, P.R. China.
Mini Rev Med Chem. 2010 Oct;10(11):1039-45. doi: 10.2174/1389557511009011039.
The atmospheric pollutant sulfur dioxide (SO(2)) is endogenously generated from the normal metabolism of sulfur-containing amino acids through the aspartate aminotransferase pathway. SO(2) is produced in cardiovascular tissues, and the aspartate aminotransferase mRNA is localized in endothelia and in vascular smooth muscle cells near the endothelial layer. Recent studies explored the physiological and pathophysiological effects of endogenous SO(2) on the cardiovascular system, and various potential mechanisms were found. These discoveries suggest a novel role of endogenous SO(2) in the modulation of the cardiovascular system and provide a basis for new treatments for cardiovascular diseases.
大气污染物二氧化硫（SO2）是通过含硫氨基酸的天冬氨酸氨基转移酶途径从正常代谢中内源性产生的。SO2 产生于心血管组织中，天冬氨酸氨基转移酶 mRNA 定位于内皮细胞以及靠近内皮层的血管平滑肌细胞中。最近的研究探索了内源性 SO2 对心血管系统的生理和病理生理影响，发现了各种潜在的机制。这些发现表明内源性 SO2 在心血管系统调节中的新作用，并为心血管疾病的新治疗方法提供了依据。
