Kolahi Jafar, Abrishami Mohamadreza, Fazilati Mohamad, Soolari Ahmad
Department of Periodontology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int Arch Med. 2010 Jun 11;3(1):9. doi: 10.1186/1755-7682-3-9.
Oral sex among teenagers is on the rise. Similarity between the oral flora and organisms recovered from nongonococcal urethritis and prostatitis, points to retrograde entry of bacteria from oral cavity into the urethra following insertive oral intercourse.
Chlorhexidine has a wide spectrum of anti-bactericidal activity encompassing gram positive and negative bacteria. It is also effective against HIV and HBV. It produced large and prolonged reductions in salivary bacterial counts within 7-h of its use. Hence, it would seem logic to postulate that rinsing with chlorhexidine before oral sex will be effective for prevention of retrograde entry of bacteria from oral cavity into the urethra. The recommendation for rinsing will be: 15 ml of a 0.12% or 10 ml of 0.2% chlorhexidine rinse for 30 seconds. Also other drug delivery systems such as chlorhexidine chewing gum or spray can be used.
Men suffering from recurrent nongonococcal urethritis or prostatitis are good subjects for testing the hypothesis. They perform genital safe sex via consistent use of condom. Yet they generally received unprotected insertive oral intercourse. Chlorhexidine can be used for prevention of recurrences of the disease.
The chlorhexidine will be a new, easy, attractive and effective method for reduction of nongonococcal urethritis, prostatitis and epidydimitis following insertive oral intercourse. It is poorly absorbed from skin, mucosa and gastrointestinal tract indicating systemic safety of chlorhexidine. The agent does not cause any bacterial resistance and supra-infection.
青少年口交行为呈上升趋势。口腔菌群与从非淋菌性尿道炎和前列腺炎中分离出的微生物之间的相似性，表明在插入式口交后细菌可从口腔逆行进入尿道。
洗必泰具有广泛的杀菌活性，涵盖革兰氏阳性菌和阴性菌。它对艾滋病毒和乙肝病毒也有效。使用后7小时内可使唾液细菌数量大幅且持续减少。因此，推测在口交前用洗必泰漱口可有效预防细菌从口腔逆行进入尿道似乎是合理的。漱口建议为：15毫升0.12%的洗必泰或10毫升0.2%的洗必泰漱口30秒。也可使用其他给药系统，如洗必泰口香糖或喷雾剂。
患有复发性非淋菌性尿道炎或前列腺炎的男性是验证该假说的理想对象。他们通过持续使用避孕套进行安全性行为。然而，他们通常接受无保护的插入式口交。洗必泰可用于预防疾病复发。
洗必泰将是一种新型、简便、有吸引力且有效的方法，可减少插入式口交后非淋菌性尿道炎、前列腺炎和附睾炎的发生。它从皮肤、黏膜和胃肠道的吸收较差，表明洗必泰具有全身安全性。该药物不会引起任何细菌耐药性和二重感染。
