MRC Human Genetics Unit and the Division of Cancer Research, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.
Cell Commun Signal. 2010 Jun 12;8:11. doi: 10.1186/1478-811X-8-11.
In the past two decades, zebrafish genetic screens have identified a wealth of mutations that have been essential to the understanding of development and disease biology. More recently, chemical screens in zebrafish have identified small molecules that can modulate specific developmental and behavioural processes. Zebrafish are a unique vertebrate system in which to study chemical genetic systems, identify drug leads, and explore new applications for known drugs. Here, we discuss some of the advantages of using zebrafish in chemical biology, and describe some important and creative examples of small molecule screening, drug discovery and target identification.
在过去的二十年中，斑马鱼遗传筛选已经确定了大量的突变，这些突变对于理解发育和疾病生物学至关重要。最近，斑马鱼的化学筛选已经确定了可以调节特定发育和行为过程的小分子。斑马鱼是研究化学遗传系统、鉴定药物先导物以及探索已知药物新应用的独特脊椎动物系统。在这里，我们讨论了在化学生物学中使用斑马鱼的一些优势，并描述了一些小分子筛选、药物发现和靶标鉴定的重要和创造性的例子。
