Raynaud F, Vivien-Roels B, Masson-Pévet M, Pévet P
URA CNRS 1332, Neurobiologie des fonctions rythmiques et saisonnières, Université Louis Pasteur, Strasbourg, France.
J Neural Transm Gen Sect. 1991;84(1-2):33-43. doi: 10.1007/BF01249107.
5-Methoxytryptamine (5-MT), 5-methoxytryptophol (5-ML) and melatonin (Mel) were measured in the plasma after 2, 5, and 8 weeks administration of 25 micrograms 5-MT to golden hamsters kept under long photoperiod. 5-MT showed a one compartment kinetic profile in the plasma with half lives of 14.8 min after 2 weeks, 15 min after 5 weeks and 19.1 min after 8 weeks. A rapid metabolism of 5-MT was shown, Mel and 5-ML being detected in the plasma following 5-MT administration. However it was also shown that the gonadal atrophy observed after 5-MT administration cannot be due to its metabolism into these 2 compounds. Indeed when exogenously administered at a dose generating the same plasma concentration as that observed after 5-MT, the gonadal regression observed after the association of 5-ML and Mel is much less than that observed after 5-MT. 5-MT is thus a compound of great physiological interest.
在给处于长光照周期的金黄仓鼠连续25微克5-甲氧基色胺（5-MT）2周、5周和8周后，测定其血浆中的5-甲氧基色胺（5-MT）、5-甲氧基色醇（5-ML）和褪黑素（Mel）。5-MT在血浆中呈现单室动力学特征，给药2周后半衰期为14.8分钟，5周后为15分钟，8周后为19.1分钟。5-MT显示出快速代谢，给药后在血浆中检测到了Mel和5-ML。然而，研究还表明，5-MT给药后观察到的性腺萎缩并非因其代谢为这两种化合物所致。事实上，当以产生与5-MT给药后相同血浆浓度的剂量外源给药时，5-ML和Mel联合给药后观察到的性腺退化远小于5-MT给药后观察到的情况。因此，5-MT是一种具有重大生理意义的化合物。
