Pévet P, Haldar-Misra C, Ocal T
J Neural Transm. 1981;51(3-4):303-11. doi: 10.1007/BF01248961.
S.c. injection of 25 microgram of methoxytryptamine (5-MT) in oil into adult male hamsters given between 4.30 and 5 p.m. (light on from 5 a.m. to 7 p.m.: 14 L/10 D) for 51 consecutive days caused involution of the testes. Similar injections of 5-MT given between 8.30 and 9.30 a.m. completely failed to cause regression of the gonads. Under the same conditions, 5-methoxytryptophan (5-MTP) did not induce gonadal atrophy, neither in the morning nor in the late afternoon. These results indicate that, like malatonin, 5-methoxytryptamine is implicated in the control of the reproductive function.
下午4点30分至5点之间（上午5点至晚上7点光照：14小时光照/10小时黑暗），向成年雄性仓鼠皮下注射溶于油中的25微克甲氧基色胺（5 - MT），连续51天，导致睾丸退化。上午8点30分至9点30分之间进行类似的5 - MT注射，完全未能引起性腺退化。在相同条件下，5 - 甲氧基色氨酸（5 - MTP）在上午或傍晚均未诱导性腺萎缩。这些结果表明，与褪黑素一样，5 - 甲氧基色胺参与生殖功能的调控。
