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本文引用的文献

1
Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency.尼群地平在肝功能不全患者中的稳态药代动力学
J Cardiovasc Pharmacol. 1984;6 Suppl 7:S977-81.
2
Bioequivalence and metabolism of nitrendipine administered orally to healthy volunteers.健康志愿者口服尼群地平后的生物等效性与代谢
J Cardiovasc Pharmacol. 1984;6 Suppl 7:S968-73.
3
Clinical experience with long-term nitrendipine treatment in essential hypertension.硝苯地平长期治疗原发性高血压的临床经验。
J Cardiovasc Pharmacol. 1984;6 Suppl 7:S1090-5.
4
Age and the metabolism of drugs.年龄与药物代谢
Q J Med. 1987 Jul;64(243):545-7.

老年高血压患者单次及多次给药后血浆尼群地平浓度

Plasma nitrendipine concentrations in elderly hypertensive patients after single and multiple dosing.

作者信息

Crome P, Baksi A, MacMahon D, Pandita-Gunawardena N D, Edwards J, Marley J

机构信息

Orpington Hospital, Kent.

出版信息

Br J Clin Pharmacol. 1988 Sep;26(3):323-6. doi: 10.1111/j.1365-2125.1988.tb05283.x.

DOI:10.1111/j.1365-2125.1988.tb05283.x
PMID:3179170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1386545/
Abstract

Twenty-three elderly hypertensive subjects received nitrendipine 10mg daily by mouth for 8 days. Plasma nitrendipine concentrations were measured after the first and last dose. There was no significant difference in plasma concentrations at any time point between the two days nor in derived pharmacokinetic measurements. Drug accumulation was not observed.

摘要

23名老年高血压患者每天口服10毫克尼群地平，共服用8天。在首次服药和末次服药后测量血浆尼群地平浓度。两天中任何时间点的血浆浓度以及推导的药代动力学测量值均无显著差异。未观察到药物蓄积。