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1
Release of pituitary growth hormone by prostaglandins and dibutyryl adenosine cyclic 3':5'-monophosphate in the absence of protein synthesis.在缺乏蛋白质合成的情况下，前列腺素和二丁酰腺苷环3',5'-单磷酸对垂体生长激素的释放作用
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1172-9. doi: 10.1073/pnas.67.3.1172.
2
The effect of prostaglandins on ox pituitary content of adenosine 3':5'-cyclic monophosphate and the release of growth hormone.前列腺素对牛垂体中3':5'-环磷酸腺苷含量及生长激素释放的影响。
Biochem J. 1972 Mar;127(1):143-54. doi: 10.1042/bj1270143.
3
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.霍乱肠毒素和前列腺素对肠黏膜腺苷酸环化酶的刺激作用。
J Clin Invest. 1971 Jun;50(6):1218-30. doi: 10.1172/JCI106599.
4
The regulation of growth hormone secretion from the isolated rat anterior pituitary in vitro. The role of adenosine 3':5'-cyclic monophosphate.体外分离大鼠垂体前叶生长激素分泌的调节。3':5'-环磷酸腺苷的作用。
Biochem J. 1971 Oct;124(4):815-26. doi: 10.1042/bj1240815.
5
Stimulation of anterior pituitary adenyl cyclase activity and adenosine 3':5'-cyclic phosphate by hypothalamic extract and prostaglandin E1.下丘脑提取物和前列腺素E1对垂体前叶腺苷酸环化酶活性及3':5'-环磷酸腺苷的刺激作用。
Proc Natl Acad Sci U S A. 1969 Jul;63(3):918-25. doi: 10.1073/pnas.63.3.918.
6
A possible role of cyclic AMP in mediating the effects of thyrotropin-releasing hormone on prolactin release and on prolactin and growth hormone synthesis in pituitary cells in culture.环磷酸腺苷在介导促甲状腺激素释放激素对培养的垂体细胞中催乳素释放以及催乳素和生长激素合成的作用方面的一种可能作用。
Endocrinology. 1976 May;98(5):1147-59. doi: 10.1210/endo-98-5-1147.
7
Stimulation of adenosine 3':5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormone.合成促黄体生成素释放激素对体外培养的垂体前叶中3':5'-环磷酸腺苷积累的刺激作用。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2677-81. doi: 10.1073/pnas.69.9.2677.
8
Dibutyryl cyclic AMP, adenosine and guanosine blockade of the dopamine, ergocryptine and apomorphine inhibition of prolactin release in vitro.二丁酰环磷腺苷、腺苷和鸟苷对多巴胺、麦角隐亭和阿扑吗啡在体外抑制催乳素释放的阻断作用。
Endocrinology. 1976 Dec;99(6):1612-7. doi: 10.1210/endo-99-6-1612.
9
Increase in pituitary adenosine 3':5'-cyclic monophosphate content and potentiation of growth-hormone release from heifer anterior pituitary slices incubated in the presence of 3-isobutyl-1-methylxanthine.在3-异丁基-1-甲基黄嘌呤存在的情况下，培养的小母牛垂体前叶切片中垂体腺苷3':5'-环磷酸含量增加以及生长激素释放增强。
Biochem J. 1974 Aug;142(2):295-300. doi: 10.1042/bj1420295.
10
Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity.人白细胞中的环3',5'-腺苷单磷酸：合成、降解及其对中性粒细胞杀念珠菌活性的影响
J Clin Invest. 1971 Apr;50(4):920-9. doi: 10.1172/JCI106564.

引用本文的文献

1
Plasminogen activators of the pituitary gland: enzyme characterization and hormonal modulation.垂体中的纤溶酶原激活剂：酶的特性及激素调节
J Cell Biol. 1983 Oct;97(4):1029-37. doi: 10.1083/jcb.97.4.1029.
2
Dopaminergic modulation of adenylate cyclase stimulation by vasoactive intestinal peptide in anterior pituitary.血管活性肠肽对垂体前叶腺苷酸环化酶刺激作用的多巴胺能调节
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6531-4. doi: 10.1073/pnas.78.10.6531.
3
Inhibitory effect of thyroid hormones on pituitary cyclic amp phosphodiesterase activity in vitro.甲状腺激素对体外垂体环磷酸腺苷磷酸二酯酶活性的抑制作用。
Neurochem Res. 1984 Jul;9(7):1011-8. doi: 10.1007/BF00964530.
4
Hormone secretion by cells dissociated from rat anterior pituitaries.从大鼠垂体前叶分离出的细胞的激素分泌。
J Cell Biol. 1973 Nov;59(2 Pt 1):276-303. doi: 10.1083/jcb.59.2.276.
5
Increase in pituitary adenosine 3':5'-cyclic monophosphate content and potentiation of growth-hormone release from heifer anterior pituitary slices incubated in the presence of 3-isobutyl-1-methylxanthine.在3-异丁基-1-甲基黄嘌呤存在的情况下，培养的小母牛垂体前叶切片中垂体腺苷3':5'-环磷酸含量增加以及生长激素释放增强。
Biochem J. 1974 Aug;142(2):295-300. doi: 10.1042/bj1420295.
6
Immunological phagocytosis: effect of drugs on phosphodiesterase activity.免疫吞噬作用：药物对磷酸二酯酶活性的影响。
Experientia. 1974 Aug 15;30(8):945-6. doi: 10.1007/BF01938377.
7
The effect of prostaglandins on ox pituitary content of adenosine 3':5'-cyclic monophosphate and the release of growth hormone.前列腺素对牛垂体中3':5'-环磷酸腺苷含量及生长激素释放的影响。
Biochem J. 1972 Mar;127(1):143-54. doi: 10.1042/bj1270143.
8
Compound 48-80 decreases adenosine 3'5'-monophosphate formation in rat peritoneal mast cells.化合物48-80可降低大鼠腹膜肥大细胞中3',5'-环磷酸腺苷的生成。
Experientia. 1973 Apr 15;29(4):447-8. doi: 10.1007/BF01926773.
9
Ultrastructure and morphometry of ACTH-producing cell in the rat anterior pituitary gland stimulated by lysin-vasopressin and prostaglandin E1.赖氨酸加压素和前列腺素E1刺激下大鼠垂体前叶促肾上腺皮质激素分泌细胞的超微结构及形态测定
Virchows Arch A Pathol Anat Histol. 1978 May 5;378(1):23-33. doi: 10.1007/BF00427183.
10
Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin.阿来他汀对前列腺素诱导的大鼠垂体前叶环磷酸腺苷积累的抑制作用。
Experientia. 1978 Apr 15;34(4):441-3. doi: 10.1007/BF01935914.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.腺苷酸环化酶。III. 儿茶酚胺和胆碱酯对心肌和肝脏制剂生成3',5'-磷酸腺苷的影响。
J Biol Chem. 1962 Apr;237:1233-8.
3
Adenyl cyclase. IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues.腺苷酸环化酶。IV. 神经激素对脑及其他组织提取物中3',5'-磷酸腺苷形成的影响。
J Biol Chem. 1962 Apr;237:1239-43.
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The role of cyclic adenylic acid in hormone action.环磷酸腺苷在激素作用中的角色。
Recent Prog Horm Res. 1960;16:121-38.
5
ELECTROPHORETIC COMPARISON OF PITUITARY GLANDS FROM MALE AND FEMALE RATS.雄性和雌性大鼠垂体的电泳比较
Endocrinology. 1965 Apr;76:578-83. doi: 10.1210/endo-76-4-578.
6
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
J Biol Chem. 1962 Apr;237:1244-50.
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Adenosine 3',5'-monophosphate as the intracellular mediator of the action of adrenocorticotropic hormone on the adrenal cortex.3',5'-环磷酸腺苷作为促肾上腺皮质激素作用于肾上腺皮质的细胞内介质。
J Biol Chem. 1967 Dec 10;242(23):5535-41.
8
Role of cyclic 3',5'-adenosine monophosphate in the release of growth hormone in vitro.环3',5'-单磷酸腺苷在体外生长激素释放中的作用。
Nature. 1967 Sep 23;215(5108):1382-3. doi: 10.1038/2151382b0.
9
Hormonal properties of transplanted pituitary tumors and their relation to the pituitary gland.移植性垂体肿瘤的激素特性及其与垂体的关系。
Endocrinology. 1966 Dec;79(6):1149-56. doi: 10.1210/endo-79-6-1149.
10
Influence of norepinephrine and catecholamine-depleting agents on the synthesis and release of prolactin and growth hormone.去甲肾上腺素和儿茶酚胺耗竭剂对催乳素和生长激素合成与释放的影响。
Endocrinology. 1969 Nov;85(5):916-23. doi: 10.1210/endo-85-5-916.

在缺乏蛋白质合成的情况下，前列腺素和二丁酰腺苷环3',5'-单磷酸对垂体生长激素的释放作用

Release of pituitary growth hormone by prostaglandins and dibutyryl adenosine cyclic 3':5'-monophosphate in the absence of protein synthesis.

作者信息

MacLeod R M, Lehmeyer J E

出版信息

Proc Natl Acad Sci U S A. 1970 Nov;67(3):1172-9. doi: 10.1073/pnas.67.3.1172.

DOI:10.1073/pnas.67.3.1172
PMID:4320973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283333/
Abstract

Effects of prostaglandins on the incorporation of [4,5-(3)H]leucine into growth hormone and its subsequent release into the incubation medium were studied. Incubation of rat anterior pituitary glands with 10(-6) M prostaglandin PGE(1) in tissue culture medium 199 for 7 hr caused a 40-300% increase in the release of labeled growth hormone into the incubation medium. PGE(1) at 10(-8) M increased growth hormone synthesis but not release. At 10(-6) M, PGE(2) had effects similar to PGE(1); PGA(1) increased growth hormone synthesis but not release. PGF(2alpha) was without effect on either synthesis or release of growth hormone.Prolactin synthesis and release were not affected by prostaglandins. All of the prostaglandins, at 10(-4) M, increased adenyl cyclase activity in the pituitary gland but phosphodiesterase activity was unaltered. Dibutyryl cyclic AMP, with or without caffeine, caused an up to 300% increase in labeled growth hormone release. No consistent effect of prolactin was observed. If potassium concentration was increased 10-fold, a 215% increase in growth hormone release was observed. A combination of hypertonic potassium and 10(-6) M PGE(1) increased growth hormone release 325%, suggesting that potassium and prostaglandins act by independent mechanisms. Addition of theophylline to pituitary gland, incubated in vitro, increased both the synthesis and release of growth hormone. Although fluoride greatly stimulated growth hormone release, it completely inhibited the incorporation of leucine into the hormone. Similarly, puromycin inhibited synthesis of growth hormone but did not block release induced by prostaglandin, dibutyryl cyclic AMP, theophylline, or fluoride. Prostaglandins increase pituitary adenyl cyclase activity and, presumably via cyclic AMP, increase growth hormone release, independently of protein synthesis.

摘要

研究了前列腺素对[4,5-(3)H]亮氨酸掺入生长激素及其随后释放到培养液中的影响。在199组织培养液中，用10(-6)M前列腺素PGE(1)孵育大鼠垂体前叶7小时，导致标记生长激素释放到培养液中的量增加40 - 300%。10(-8)M的PGE(1)增加生长激素的合成但不增加释放。10(-6)M时，PGE(2)的作用与PGE(1)相似；PGA(1)增加生长激素的合成但不增加释放。PGF(2α)对生长激素的合成或释放均无影响。催乳素的合成和释放不受前列腺素影响。所有前列腺素在10(-4)M时均增加垂体腺苷酸环化酶活性，但磷酸二酯酶活性未改变。二丁酰环磷腺苷，无论有无咖啡因，均可使标记生长激素释放增加达300%。未观察到催乳素的一致作用。如果钾浓度增加10倍，生长激素释放增加215%。高渗钾与10(-6)M PGE(1)联合使用使生长激素释放增加325%，提示钾和前列腺素通过独立机制起作用。在体外孵育的垂体中加入茶碱，可增加生长激素的合成和释放。虽然氟化物极大地刺激生长激素释放，但它完全抑制亮氨酸掺入该激素。同样，嘌呤霉素抑制生长激素的合成，但不阻断前列腺素、二丁酰环磷腺苷、茶碱或氟化物诱导的释放。前列腺素增加垂体腺苷酸环化酶活性，并可能通过环磷腺苷，独立于蛋白质合成增加生长激素释放。