Aronson P J, Chambers M C, Taniguchi Y, Ito K, Griner J M, Kagetsu N, Hashimoto K
Department of Dermatology and Syphilogy, Wayne State University School of Medicine, Detroit, Michigan 48201.
J Dermatol Sci. 1991 Jan;2(1):33-44. doi: 10.1016/0923-1811(91)90040-5.
Dermal reactions to primary intradermal or appendageal sensitization are compared to predominantly dermal reactions to standard patch tests and to intradermal antigen tests. In contrast to epicutaneous spongiotic contact dermatitis, HLA-DR was only seen on skin appendages and nearby basal keratinocytes in indurated tissue reactions with the exception of the reactions with focal basal cell layer disruption and an indurated patch test performed one week post angry back syndrome. Other intradermal skin tests showed only minimal epidermal HLA-DR expression despite spongiotic epidermal changes. Predominantly dermal hypersensitivity reactions can be induced by intradermal or epicutaneous routes. They can evoke hypersensitivity responses which do not cause most epidermal keratinocytes to express HLA-DR.
将原发性皮内或附属器致敏引起的皮肤反应与标准斑贴试验及皮内抗原试验引起的主要为皮肤的反应进行比较。与表皮海绵状接触性皮炎不同，除了伴有局灶性基底细胞层破坏的反应以及“愤怒背”综合征后一周进行的硬结斑贴试验外，HLA-DR仅在硬结组织反应的皮肤附属器及附近的基底角质形成细胞上可见。其他皮内皮肤试验尽管有表皮海绵状改变，但仅显示出最小程度的表皮HLA-DR表达。主要为皮肤的超敏反应可通过皮内或表皮途径诱发。它们可引发超敏反应，而这些反应不会导致大多数表皮角质形成细胞表达HLA-DR。
