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Delivery of siRNA therapeutics: barriers and carriers.siRNA 治疗药物的递送：障碍与载体。
AAPS J. 2010 Dec;12(4):492-503. doi: 10.1208/s12248-010-9210-4. Epub 2010 Jun 11.
2
Supramolecular assemblies in functional siRNA delivery: where do we stand?功能性 siRNA 递送上的超分子组装：我们处于什么位置？
Biomaterials. 2012 Mar;33(8):2546-69. doi: 10.1016/j.biomaterials.2011.11.079. Epub 2011 Dec 30.
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siRNA based drug design, quality, delivery and clinical translation.基于 siRNA 的药物设计、质量、传递和临床转化。
Nanomedicine. 2020 Oct;29:102239. doi: 10.1016/j.nano.2020.102239. Epub 2020 Jun 13.
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siRNA therapeutics: a clinical reality.siRNA 疗法：临床现实。
Sci China Life Sci. 2020 Apr;63(4):485-500. doi: 10.1007/s11427-018-9438-y. Epub 2019 Apr 30.
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Efficient and targeted delivery of siRNA in vivo.体内 siRNA 的高效和靶向递送。
FEBS J. 2010 Dec;277(23):4814-27. doi: 10.1111/j.1742-4658.2010.07904.x.
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Delivery of siRNA to the target cell cytoplasm: photochemical internalization facilitates endosomal escape and improves silencing efficiency, in vitro and in vivo.将小干扰RNA（siRNA）递送至靶细胞胞质：光化学内化促进内体逃逸并提高体内外沉默效率。
Curr Pharm Des. 2008;14(34):3686-97. doi: 10.2174/138161208786898789.
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Polycation-based nanoparticle delivery for improved RNA interference therapeutics.基于聚阳离子的纳米颗粒递送用于改善RNA干扰疗法。
Expert Opin Biol Ther. 2007 Dec;7(12):1811-22. doi: 10.1517/14712598.7.12.1811.
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PAMAM Dendrimers as a Delivery System for Small Interfering RNA.PAMAM 树枝状聚合物作为小干扰 RNA 的递送系统。
Methods Mol Biol. 2020;2115:91-106. doi: 10.1007/978-1-0716-0290-4_5.
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Non-viral nanosystems for systemic siRNA delivery.用于系统性 siRNA 递送的非病毒纳米系统。
Pharmacol Res. 2010 Aug;62(2):100-14. doi: 10.1016/j.phrs.2009.11.013. Epub 2009 Dec 17.
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A Dual Targeting Dendrimer-Mediated siRNA Delivery System for Effective Gene Silencing in Cancer Therapy.一种用于癌症治疗中有效基因沉默的双重靶向树枝状聚合物介导的 siRNA 传递系统。
J Am Chem Soc. 2018 Nov 28;140(47):16264-16274. doi: 10.1021/jacs.8b10021. Epub 2018 Nov 1.
引用本文的文献
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Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants.小干扰RNA介导的病毒基因沉默治疗方法：预防抗病毒耐药逃逸突变体出现的策略
Pharmaceuticals (Basel). 2025 Jul 1;18(7):987. doi: 10.3390/ph18070987.
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Intravenous Administration of sRNA Nanoparticles for Treatment of Osteoporosis in Mice.静脉注射sRNA纳米颗粒用于治疗小鼠骨质疏松症
Pharmaceutics. 2025 Jun 17;17(6):789. doi: 10.3390/pharmaceutics17060789.
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Autologous platelet delivery of siRNAs by autologous plasma protein self-assembled nanoparticles for the treatment of acute kidney injury.通过自体血浆蛋白自组装纳米颗粒进行小干扰RNA的自体血小板递送用于治疗急性肾损伤。
J Nanobiotechnology. 2025 Mar 29;23(1):256. doi: 10.1186/s12951-025-03338-6.
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Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies.肺动脉高压：分子机制与临床研究
MedComm (2020). 2025 Mar 10;6(3):e70134. doi: 10.1002/mco2.70134. eCollection 2025 Mar.
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Injured Cardiac Tissue-Targeted Delivery of TGFβ1 siRNA by FAP Aptamer-Functionalized Extracellular Vesicles Promotes Cardiac Repair.通过FAP适配体功能化细胞外囊泡实现对损伤心脏组织的靶向递送TGFβ1 siRNA可促进心脏修复。
Int J Nanomedicine. 2025 Mar 1;20:2575-2592. doi: 10.2147/IJN.S497428. eCollection 2025.
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Multi-functional near-infrared fluorescent polymer dot-siRNA for gene expression regulation.用于基因表达调控的多功能近红外荧光聚合物点-小干扰RNA
J Mater Chem B. 2025 Feb 5;13(6):2124-2139. doi: 10.1039/d4tb01954g.
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CRISPR-Cas13a Targeting the FGFR3-TACC3 Fusion Gene Inhibits Proliferation of Bladder Cancer Cells in vitro and in vivo.靶向FGFR3-TACC3融合基因的CRISPR-Cas13a在体内外抑制膀胱癌细胞增殖
Onco Targets Ther. 2024 Dec 18;17:1197-1207. doi: 10.2147/OTT.S492659. eCollection 2024.
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Advanced siRNA delivery in combating hepatitis B virus: mechanistic insights and recent updates.抗乙型肝炎病毒的高级 siRNA 递呈：机制见解和最新进展。
J Nanobiotechnology. 2024 Nov 30;22(1):745. doi: 10.1186/s12951-024-03004-3.
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Exploring the potential of nanomedicine for gene therapy across the physicochemical and cellular barriers.探索纳米医学跨越物理化学和细胞屏障用于基因治疗的潜力。
Funct Integr Genomics. 2024 Sep 28;24(5):177. doi: 10.1007/s10142-024-01459-z.
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Improving Skin Cancer Treatment by Dual Drug Co-Encapsulation into Liposomal Systems-An Integrated Approach towards Anticancer Synergism and Targeted Delivery.通过将双药共包封到脂质体系统中来改善皮肤癌治疗——一种实现抗癌协同作用和靶向递送的综合方法
Pharmaceutics. 2024 Sep 12;16(9):1200. doi: 10.3390/pharmaceutics16091200.
本文引用的文献
1
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.经靶向纳米粒系统给药的 siRNA 在人体中 RNAi 的证据。
Nature. 2010 Apr 15;464(7291):1067-70. doi: 10.1038/nature08956. Epub 2010 Mar 21.
2
Cutaneous short-interfering RNA therapy.皮肤的小干扰 RNA 治疗。
Expert Opin Drug Deliv. 2009 Dec;6(12):1333-49. doi: 10.1517/17425240903304032.
3
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.优化的适体-小干扰RNA嵌合体的全身给药促进表达前列腺特异性膜抗原（PSMA）的肿瘤消退。
Nat Biotechnol. 2009 Sep;27(9):839-49. doi: 10.1038/nbt.1560. Epub 2009 Aug 23.
4
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery.表面工程靶向 PPI 树状聚合物用于高效细胞内和肿瘤内 siRNA 递送。
J Control Release. 2009 Dec 16;140(3):284-93. doi: 10.1016/j.jconrel.2009.06.019. Epub 2009 Jun 28.
5
Small silencing RNAs: state-of-the-art.小干扰RNA：最新进展
Adv Drug Deliv Rev. 2009 Jul 25;61(9):672-703. doi: 10.1016/j.addr.2009.05.002. Epub 2009 May 7.
6
siRNA delivery systems for cancer treatment.用于癌症治疗的小干扰RNA递送系统。
Adv Drug Deliv Rev. 2009 Aug 10;61(10):850-62. doi: 10.1016/j.addr.2009.04.018. Epub 2009 May 5.
7
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA.使用负载有小干扰RNA的可生物降解聚合物纳米颗粒进行阴道内基因沉默。
Nat Mater. 2009 Jun;8(6):526-33. doi: 10.1038/nmat2444. Epub 2009 May 3.
8
siRNA vs. shRNA: similarities and differences.小干扰RNA与短发夹RNA：异同点
Adv Drug Deliv Rev. 2009 Jul 25;61(9):746-59. doi: 10.1016/j.addr.2009.04.004. Epub 2009 Apr 20.
9
Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy.非病毒载体介导的RNA干扰：其基因沉默特性及实现基于RNA干扰的基因治疗的重要因素。
Adv Drug Deliv Rev. 2009 Jul 25;61(9):760-6. doi: 10.1016/j.addr.2009.04.006. Epub 2009 Apr 20.
10
Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape.使用经修饰以实现内体逃逸的细胞穿透肽进行细胞内小干扰RNA递送。
Adv Drug Deliv Rev. 2009 Jul 25;61(9):704-9. doi: 10.1016/j.addr.2009.04.005. Epub 2009 Apr 19.
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