Fraile J M, Puig J G, Torres Rosa J, de Miguel Eugenio, Martínez Pedro, Vázquez J J
Division of Internal Medicine, La Paz University Hospital, Madrid, Spain.
Nucleosides Nucleotides Nucleic Acids. 2010 Jun;29(4-6):330-4. doi: 10.1080/15257771003741273.
Forty-four patients (40 males) with a mean age of 58 years were included in this pilot study. Mean serum urate concentration in patients with and without the metabolic syndrome (MS) was 8.8 mg/dL and 8.1 mg/dL, respectively. Urinary uric acid excretion was 543 mg/day/1.73 m(2) in the former and 609 mg/day/1.73 m(2) in the latter. Uric acid to creatinine ratio was 0.37 mg/mg in patients with the MS and 0.42 mg/mg in those without the MS. Mean serum urate increased from 8.6 mg/dL in subjects with three or more MS components to 10.3 mg/dL in those with five MS components. Serum urate was markedly lower in patients with mild MS (9 patients, 8.6 mg/dL) as compared to severe MS (10 patients, 9.2 mg/dL). In contrast, urinary uric acid to creatinine ratio was 0.42 mg/mg in patients with gout and mild MS and 0.33 mg/mg in gout patients with severe MS. Uric acid underexcretion appears to be more severe in gout patients with the MS. This disturbance appears to be related to the severity of the MS.
本初步研究纳入了44例患者（40例男性），平均年龄58岁。患有和未患有代谢综合征（MS）的患者血清尿酸盐平均浓度分别为8.8mg/dL和8.1mg/dL。前者尿尿酸排泄量为543mg/天/1.73m²，后者为609mg/天/1.73m²。MS患者尿酸与肌酐比值为0.37mg/mg，无MS患者为0.42mg/mg。血清尿酸盐均值从具有三个或更多MS组分的受试者的8.6mg/dL增加到具有五个MS组分的受试者的10.3mg/dL。轻度MS患者（9例，8.6mg/dL）的血清尿酸盐明显低于重度MS患者（10例，9.2mg/dL）。相比之下，痛风合并轻度MS患者的尿尿酸与肌酐比值为0.42mg/mg，痛风合并重度MS患者为0.33mg/mg。尿酸排泄不足在合并MS的痛风患者中似乎更严重。这种紊乱似乎与MS的严重程度有关。
