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粉红色尿综合征:胰岛素抵抗与丙泊酚的联合作用

Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol.

作者信息

Tucker Bryan M, Perazella Mark A

机构信息

Wake Forest School of Medicine, Department of Internal Medicine, Section of Nephrology, Winston-Salem, North Carolina, USA.

Yale University School of Medicine, Section of Nephrology, New Haven, Connecticut, USA.

出版信息

Kidney Int Rep. 2018 Oct 13;4(1):30-39. doi: 10.1016/j.ekir.2018.10.009. eCollection 2019 Jan.

DOI:10.1016/j.ekir.2018.10.009
PMID:30596166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6308841/
Abstract

Pink urine syndrome is mostly seen in patients treated with propofol anesthesia. The pink color is attributed to the presence of large concentrations of uric acid (and pigment), which is excreted in large amounts when propofol is given. We describe a case of propofol-induced pink urine syndrome and perform a comprehensive, evidence-based review. We discuss prior case studies already published in the literature as we speculate on the pathophysiology and how it translates to a clinically relevant entity.

摘要

粉红色尿综合征多见于接受丙泊酚麻醉的患者。尿液呈粉红色是由于存在大量尿酸(和色素),在给予丙泊酚时会大量排出。我们描述了一例丙泊酚诱发的粉红色尿综合征病例,并进行了全面的、基于证据的综述。在推测其病理生理学以及它如何转化为一个临床相关实体时,我们讨论了文献中已发表的既往病例研究。

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Pink Urine Syndrome: A Combination of Insulin Resistance and Propofol.粉红色尿综合征:胰岛素抵抗与丙泊酚的联合作用
Kidney Int Rep. 2018 Oct 13;4(1):30-39. doi: 10.1016/j.ekir.2018.10.009. eCollection 2019 Jan.
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Case Report: Pink Urine Syndrome Following Exposure to Propofol: A Rare, Impressive but Benign Complication.病例报告:丙泊酚暴露后出现的粉红色尿综合征:一种罕见、显著但良性的并发症。
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Pink urine after propofol anesthesia.丙泊酚麻醉后出现粉红色尿液。
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Pink urine during propofol anesthesia.
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Does use of propofol in heavy alcohol drinkers tend to discolor their urine?重度饮酒者使用丙泊酚会使其尿液变色吗?
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Uric acid excretion increases during propofol anesthesia.异丙酚麻醉期间尿酸排泄增加。
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An analysis of green discoloration of urine caused by propofol infusion.丙泊酚输注引起尿液绿色变色的分析。
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Case Report: Pink Urine Syndrome Following Exposure to Propofol: A Rare, Impressive but Benign Complication.病例报告:丙泊酚暴露后出现的粉红色尿综合征:一种罕见、显著但良性的并发症。
Front Pharmacol. 2021 Jun 15;12:686619. doi: 10.3389/fphar.2021.686619. eCollection 2021.

本文引用的文献

1
The physiology of uric acid and the impact of end-stage kidney disease and dialysis.尿酸的生理学以及终末期肾病和透析的影响。
Semin Dial. 2019 Jan;32(1):47-57. doi: 10.1111/sdi.12735. Epub 2018 Jul 10.
2
Mediators of the Effects of Gender on Uric Acid Nephrolithiasis: A Novel Application of Structural Equation Modeling.性别对尿酸肾结石影响的中介因素:结构方程模型的新应用。
Sci Rep. 2018 Apr 17;8(1):6077. doi: 10.1038/s41598-018-24485-x.
3
Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics.
基于尿酸动力学半机制暴露-反应模型的高尿酸血症个体化治疗策略
Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13614.
4
URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia.西班牙肾性低尿酸血症患者的 URAT1 和 GLUT9 突变。
Clin Chim Acta. 2018 Jun;481:83-89. doi: 10.1016/j.cca.2018.02.030. Epub 2018 Feb 24.
5
Mechanism for higher urine pH in normal women compared with men.正常女性尿液 pH 值高于男性的机制。
Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F623-F629. doi: 10.1152/ajprenal.00494.2017. Epub 2017 Dec 20.
6
Novel Therapies for Acute Kidney Injury.急性肾损伤的新型疗法
Kidney Int Rep. 2017 Jun 28;2(5):785-799. doi: 10.1016/j.ekir.2017.06.020. eCollection 2017 Sep.
7
Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2.胰岛素通过调节尿酸转运蛋白1和ATP结合盒亚家族G成员2来刺激尿酸重吸收。
Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F826-F834. doi: 10.1152/ajprenal.00012.2017. Epub 2017 Jul 5.
8
HMOX1 as a marker of iron excess-induced adipose tissue dysfunction, affecting glucose uptake and respiratory capacity in human adipocytes.HMOX1作为铁过量诱导的脂肪组织功能障碍的标志物,影响人类脂肪细胞的葡萄糖摄取和呼吸能力。
Diabetologia. 2017 May;60(5):915-926. doi: 10.1007/s00125-017-4228-0. Epub 2017 Feb 27.
9
An analysis of green discoloration of urine caused by propofol infusion.丙泊酚输注引起尿液绿色变色的分析。
J Clin Anesth. 2016 Dec;35:358-360. doi: 10.1016/j.jclinane.2016.08.032. Epub 2016 Oct 13.
10
Length Polymorphisms in Heme Oxygenase-1 and AKI after Cardiac Surgery.心脏手术后血红素加氧酶-1的长度多态性与急性肾损伤
J Am Soc Nephrol. 2016 Nov;27(11):3291-3297. doi: 10.1681/ASN.2016010038. Epub 2016 Jun 2.