Johnson Philip J, Wiedmeyer Charles E, LaCarrubba Alison, Ganjam V K, Messer Nat T
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.
J Diabetes Sci Technol. 2012 May 1;6(3):534-40. doi: 10.1177/193229681200600307.
Analogous to the situation in human medicine, contemporary practices in horse management, which incorporate lengthy periods of physical inactivity coupled with provision of nutritional rations characterized by inappropriately high sugar and starch, have led to obesity being more commonly recognized by practitioners of equine veterinary practice. In many of these cases, obesity is associated with insulin resistance (IR) and glucose intolerance. An equine metabolic syndrome (MS) has been described that is similar to the human MS in that both IR and aspects of obesity represent cornerstones of its definition. Unlike its human counterpart, identification of the equine metabolic syndrome (EMS) portends greater risk for development of laminitis, a chronic, crippling affliction of the equine hoof. When severe, laminitis sometimes necessitates euthanasia. Unlike the human condition, the risk of developing type 2 diabetes mellitus and many other chronic conditions, for which the risk is recognized as increased in the face of MS, is less likely in horses. The equine veterinary literature has been replete with reports of scientific investigations regarding the epidemiology, pathophysiology, and treatment of EMS.
与人类医学的情况类似，现代马匹管理实践包括长时间的身体不活动以及提供含糖和淀粉过高的不适当营养配给，这使得马匹兽医从业者更常认识到肥胖问题。在许多此类案例中，肥胖与胰岛素抵抗（IR）和葡萄糖不耐受有关。已经描述了一种马代谢综合征（MS），它与人类MS相似，因为IR和肥胖方面都是其定义的基石。与人类不同的是，马代谢综合征（EMS）的识别预示着蹄叶炎发病风险更高，蹄叶炎是马蹄的一种慢性致残性疾病。严重时，蹄叶炎有时需要实施安乐死。与人类情况不同，面对MS时2型糖尿病和许多其他慢性病风险增加，而在马匹中发生这些疾病的可能性较小。马兽医文献中充斥着关于EMS流行病学、病理生理学和治疗的科学研究报告。
