[精氨酸加压素对神经症大鼠脑结构兴奋性和脂肪酸含量的影响]
[The effect of arginine vasopressin on the excitability and fatty acid content of the brain structures in rats with a neurosis].
作者信息
Nerush P A
出版信息
Biull Eksp Biol Med. 1991 Mar;111(3):271-4.
Experiments on rats with chronic bipolar electrodes implanted into the frontal cortex (FC), dorsal hippocampus (DH) and midbrain reticular formation (RF) established that the neurotic state (model "conflict of afferent excitation") was characterised by the increase in structure excitability: FC--15.4% (P less than 0.01), DH--12.4% (P = 0.05) and RF--17.5% (P less than 0.001). The presence of free fatty acids (FFA) revealed by chromatograph Schimadzu in brain cortex (BC), hippocampus (H) and midbrain (MB) in acute experiments evidenced the increase in the level of linolinic acid in all matters within the limits of 64-162% (P less than 0.05) and also different changes in arachidonic acid in BC and subcortical structures. The level of arachidonic acid increased by 120% (P less than 0.01) in BC but it decreased in H and MB within the limits of 34-56%. AVP (1 micrograms/kg) decreased excitability of FC by 6% (P less than 0.001), of H--by 8% (P less than 0.01) and RF--by 6%. In this case FFA, especially arachidonic acid, was increased in H and MB (by 2.5-6 times). The quantity of palmitic, stearic and oleic acids increased.
对植入额叶皮质（FC）、背侧海马体（DH）和中脑网状结构（RF）的慢性双极电极的大鼠进行的实验表明，神经症状态（“传入兴奋冲突”模型）的特征是结构兴奋性增加：FC增加15.4%（P<0.01），DH增加12.4%（P = 0.05），RF增加17.5%（P<0.001）。在急性实验中，岛津色谱仪在大脑皮质（BC）、海马体（H）和中脑（MB）中检测到游离脂肪酸（FFA）的存在，这证明所有物质中亚油酸水平增加了64 - 162%（P<0.05），并且BC和皮质下结构中花生四烯酸也有不同变化。BC中花生四烯酸水平增加了120%（P<0.01），但在H和MB中降低了34 - 56%。血管加压素（1微克/千克）使FC的兴奋性降低6%（P<0.001），H降低8%（P<0.01），RF降低6%。在这种情况下，H和MB中的FFA，尤其是花生四烯酸增加了（2.5 - 6倍）。棕榈酸、硬脂酸和油酸的量增加。
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