Nerush P A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Nov-Dec;38(6):1152-7.
Formation of experimental neurosis in rats was accompanied in 64% of animals by development of amnesia of conditioned reaction of passive avoidance. Disturbance of mnestic processes was manifested by a change in free amino acids pool including the acids with neurotransmitter properties (GABA, glutamate, glycine). An increase of GABA and glycine content was found in the frontal cortex and an increase of glutamate and GABA--in the hippocampus and striate body. Substance P (125 mkg/kg) administered intraperitoneally against the background of a developed neurosis, produced in 80% of cases an antiamnestic action, accompanied by a statistically significant decrease of GABA content in the frontal cortex, hippocampus and midbrain, and an increase of glutamate in the midbrain. The level of taurine decreased in the frontal cortex, hippocampus and striate body, and increased in the midbrain. Threonine content increased in the striate body and midbrain; there was an increase of taurine, serine and glycine in the midbrain and of glycine in the striate body.
在大鼠实验性神经症形成过程中，64%的动物出现被动回避条件反应失忆。记忆过程的紊乱表现为游离氨基酸池的变化，包括具有神经递质特性的氨基酸（γ-氨基丁酸、谷氨酸、甘氨酸）。在额叶皮质中发现γ-氨基丁酸和甘氨酸含量增加，在海马体和纹状体中谷氨酸和γ-氨基丁酸含量增加。在已形成神经症的背景下腹腔注射P物质（125微克/千克），80%的情况下产生抗失忆作用，同时额叶皮质、海马体和中脑中γ-氨基丁酸含量有统计学意义的下降，中脑中谷氨酸含量增加。额叶皮质、海马体和纹状体中牛磺酸水平下降，中脑中牛磺酸水平升高。纹状体和中脑中苏氨酸含量增加；中脑中牛磺酸、丝氨酸和甘氨酸增加，纹状体中甘氨酸增加。
