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[γ-氨基丁酸(GABA)能药物对脑结构作用的神经生理机制]

[Neurophysiological mechanisms of the action of GABA-tropic agents on brain structures].

作者信息

Krauz V A, Mamchur V I, Iarosh A K

出版信息

Farmakol Toksikol. 1987 Nov-Dec;50(6):30-3.

PMID:2830132
Abstract

The effect of systemic administration of agonists and antagonists of GABA system on excitability and intracentral relationships of the brain structures was found during chronic experiments on rabbits with bipolar electrodes implanted in the region of the frontal cortex, dorsal hippocampus, midbrain reticular formation and central gray matter. The changes of the functional state of the cerebral formations were suggested to be related to a different degree of the involvement of GABA receptors of types A and B.

摘要

在对家兔进行的慢性实验中,将双极电极植入额叶皮质、背侧海马、中脑网状结构和中央灰质区域,发现全身性给予γ-氨基丁酸(GABA)系统的激动剂和拮抗剂对脑结构的兴奋性及中枢内关系有影响。推测脑结构功能状态的变化与不同程度参与A 型和 B 型GABA 受体有关。

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