Gol'dina O A, Moskvitina T A, Gankina E M, Kirkel' A Z, Kamyshanskaia N S, Lopatina K I, Sokolova T V, Zagorevskiĭ V A, Val'dman A V, Gorkin V Z
Biull Eksp Biol Med. 1991 Mar;111(3):279-80.
The effect on deamination of serotonine, dopamine, tiramine and 2-phenylamine of benzamide derivatives befol, moclobemide and LIS-641 was studied. Befol and moclobemide are inhibitors of serotonine deaminating activity of MAO. The different sensitivity of this activity to the effect of the benzamide derivatives in beef or rat brain and human placenta was noted. The inhibition was more distinct in tissue homogenate than in corresponding mitochondrial fractions.
研究了苯甲酰胺衍生物贝福洛尔、吗氯贝胺和LIS-641对血清素、多巴胺、酪胺和2-苯胺脱氨基作用的影响。贝福洛尔和吗氯贝胺是单胺氧化酶血清素脱氨基活性的抑制剂。注意到该活性对牛肉、大鼠脑和人胎盘中苯甲酰胺衍生物作用的不同敏感性。在组织匀浆中的抑制作用比在相应的线粒体组分中更明显。
