[经胎盘暴露于钴胺辅酶和亚叶酸的小鼠肾脏器官培养物中N-亚硝基-N-乙基脲的致癌活性]
[The carcinogenic activity of N-nitroso-N-ethylurea in kidney organ cultures of mice exposed transplacentally to cobalamin coenzymes and folinic acid].
作者信息
Golenko O D, Ryzhova N I, Miasishcheva N V
出版信息
Biull Eksp Biol Med. 1991 Mar;111(3):292-4.
Preneoplastic changes in organ cultures of mouse embryonic kidney (OCEK) under transplacental N-nitrosoethyl urea (ENU) did not increase under the influence of Ado-Cbl. The frequency of focal proliferation in OCEK under transplacental influence of Ado-C bl and ENU was 2.2 times less than the combination of carcinogen with MeCbl (32.2% and 71.9%, respectively, P less than 0.01). The number of DNA-synthesising epithelial cells in OCEK were less under transplacental influence of Ado-Cbl (8.6 +/- 1.4%) than in MeCbl or FA (19.4 +/- 1.8% and 16.2 +/- 1.3% respectively, P less than 0.01).
在经胎盘给予N-亚硝基乙基脲（ENU）的情况下，转钴胺素A（Ado-Cbl）并未使小鼠胚胎肾器官培养物（OCEK）中的癌前病变增加。在经胎盘给予Ado-Cbl和ENU的影响下，OCEK中局灶性增殖的频率比致癌物与甲钴胺（MeCbl）联合使用时低2.2倍（分别为32.2%和71.9%，P<0.01）。在经胎盘给予Ado-Cbl的影响下，OCEK中DNA合成上皮细胞的数量比在MeCbl或叶酸（FA）中少（分别为8.6±1.4%、19.4±1.8%和16.2±1.3%，P<0.01）。
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