Jung G, Millon-Collard R, Abecassis J
Laboratoire d'hématologie, centre hospitalier général de Mulhouse, France.
Bull Cancer. 1991;78(3):253-60.
The ability of tumor cells to initiate coagulation, platelet aggregation and subsequent thrombotic alterations is believed to facilitate metastatic process. The mechanisms by which tumor cells develop thrombotic events in malignancy are discussed. We have examined the procoagulant activity and the modifications of rheologic platelet functions induced by 3 human mammary tumor cell lines (MCF-7, ZR-75-1, BT-20) using a laser-thromborheometer. According to experimental conditions, these 3 tumor cell lines aggregate platelets via a thrombin-dependent mechanism. Moreover, MCF-7 cells also induce ADP-like platelet aggregation. These data suggest the existence of several mechanisms of mammary tumor cell-induced platelet aggregation.
肿瘤细胞引发凝血、血小板聚集及随后血栓形成改变的能力被认为有助于转移过程。本文讨论了肿瘤细胞在恶性肿瘤中引发血栓形成事件的机制。我们使用激光血栓流变仪检测了3种人乳腺肿瘤细胞系（MCF-7、ZR-75-1、BT-20）诱导的促凝活性和血小板流变学功能的改变。根据实验条件，这3种肿瘤细胞系通过凝血酶依赖性机制使血小板聚集。此外，MCF-7细胞还诱导类似ADP的血小板聚集。这些数据表明存在多种乳腺肿瘤细胞诱导血小板聚集的机制。
