Chemistry Department, Federal University of Parana, PO Box 19081, Curitiba 81531-990, PR Brazil.
Adv Exp Med Biol. 2010;672:203-10. doi: 10.1007/978-1-4419-5979-9_15.
In recent years biosurfactants have attracted attention because of their low toxicity, biodegradability and ecological acceptability. However, their use is currently extremely limited due to their high cost in relation to that of chemical surfactants. Solid-state cultivation represents an alternative technology for biosurfactant production that can bring two important advantages: firstly, it allows the use of inexpensive substrates and, secondly, it avoids the problem of foaming that complicates submerged cultivation processes for biosurfactant production. In this chapter we show that, despite its potential, to date relatively little attention has been given to solid-state cultivation for biosurfactant production. We also note that this cultivation technique brings its own challenges, such as the selection of a bioreactor type that will allow adequate heat removal, of substrates with appropriate physico-chemical properties and of methods for monitoring of the cultivation process and recovering the biosurfactants from the fermented solid. With suitable efforts in research, solid-state cultivation can be used for large-scale production of biosurfactants.
近年来，生物表面活性剂因其低毒性、可生物降解性和生态可接受性而引起了人们的关注。然而，由于其成本与化学表面活性剂相比过高，其应用目前受到极大限制。固态培养代表了一种生产生物表面活性剂的替代技术，它可以带来两个重要的优势：首先，它允许使用廉价的基质；其次，它避免了泡沫问题，而泡沫问题会使生物表面活性剂生产的深层培养过程复杂化。在本章中，我们表明，尽管具有潜力，但迄今为止，固态培养在生物表面活性剂生产中的应用相对较少。我们还注意到，这种培养技术带来了自身的挑战，例如选择能够充分去除热量的生物反应器类型、选择具有适当物理化学性质的基质，以及选择监测培养过程和从发酵固体中回收生物表面活性剂的方法。通过在研究方面做出适当的努力，固态培养可以用于大规模生产生物表面活性剂。
